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Baseline data on distribution of human papillomavirus (HPV-) genotypes in cervical samples of gynecological patients before implementation of population-based HPV- vaccination program in Polande implementation of population-based HPV vaccination program in Poland.
Glinska, Patrycja; Macios, Anna; Jaworski, Rafal; Bobinski, Marcin; Pruski, Dominik; Przybylski, Marcin; Zielinska, Aleksandra; Sawicki, Wlodzimierz; Nowakowski, Andrzej.
Afiliación
  • Glinska P; Department of Oncological Gastroenterology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland. Patrycja.Glinska@nio.gov.pl.
  • Macios A; Warsaw PhD School in Natural and BioMedical Sciences, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland. Patrycja.Glinska@nio.gov.pl.
  • Jaworski R; Department of Cancer Prevention, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
  • Bobinski M; Doctoral School of Translational Medicine, Centre of Postagraduate Medical Education, Warsaw, Poland.
  • Pruski D; MSD, Warsaw, Poland.
  • Przybylski M; 1st Chair and Department of Gynaecological Oncology and Gynaecology, Medical University in Lublin, Lublin, Poland.
  • Zielinska A; Department of Obstetrics and Gynecology, District Public Hospital in Poznan, Poland, Poland.
  • Sawicki W; Department of Obstetrics and Gynecology, District Public Hospital in Poznan, Poland, Poland.
  • Nowakowski A; Chair and Department of Obstetrics, Gynecology and Gynecological Oncology, Medical University of Warsaw, Poland.
Ginekol Pol ; 2024 Sep 17.
Article en En | MEDLINE | ID: mdl-39287203
ABSTRACT

OBJECTIVES:

Free-of-charge vaccination against human papillomavirus (HPV-) of 12-13-year-old teenagers was introduced on the 1st of June 2023 in Poland. Data on baseline HPV- genotype cervical distribution are crucial to evaluate potential changes after full implementation of the vaccination program. We aimed at evaluating the status of HPV- infection and distribution of HPV- genotypes in cervical cytology of gynecological patients tested in one of the largest HPV- laboratories in Poland. MATERIAL AND

METHODS:

Data on all HPV- tests performed in ALAB Laboratoria Sp. z o. o. in Poland in 2018-2021 were analyzed, focusing on tests that identified genotypes 6, 11, 16, 18, 26, 31, 33, 35, 39, 40, 42, 44, 45, 51, 52, 53, 54, 56, 58, 59, 61, 62, 66, 67, 68, 70, 73, 81, 82, 83, 89. Distribution of HPV- genotypes was assessed among HPV--positive women.

RESULTS:

Among 11.151 medical records retrieved in women with valid HPV- test results, 5.681 were positive (50.9%), of whom 2.929 were infected with a single genotype (51.6%). At least one high-risk (HR) genotype was detected in 4.351 women (76.6%). Among all HPV--positive women, the most common HR genotypes were HPV--16, HPV--31 and HPV--66 (24.0%, 11.3%, 11.3%, respectively). HPV--53 was the most prevalent among non-HR types (10.5%).

CONCLUSIONS:

HPV--16 followed by HPV--31 and HPV--66 were the most frequent genotypes in the studied cohort. These results may be compared with the same methodology after full roll-out of HPV- vaccination program in the future to track potential changes in HPV- genotype distribution.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Ginekol Pol Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Polonia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Ginekol Pol Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Polonia