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Further evidence that peritraumatic 17ß-estradiol levels influence chronic posttraumatic pain outcomes in women, data from both humans and animals.
Son, Esther; Gaither, Rachel; Lobo, Jarred; Zhao, Ying; McKibben, Lauren A; Arora, Rhea; Albertorio-Sáez, Liz; Mickelson, Jacqueline; Wanstrath, Britannia J; Bhatia, Simran; Stevens, Jennifer S; Jovanovic, Tanja; Koenen, Karestan; Kessler, Ronald; Ressler, Kerry; Beaudoin, Francesca L; McLean, Samuel A; Linnstaedt, Sarah D.
Afiliación
  • Son E; Department of Anesthesiology, University of North Carolina, Chapel Hill, NC, United States.
  • Gaither R; Institute for Trauma Recovery, University of North Carolina, Chapel Hill, NC, United States.
  • Lobo J; Department of Epidemiology, Brown University School of Public Health, Providence, RI, United States.
  • Zhao Y; Department of Anesthesiology, University of North Carolina, Chapel Hill, NC, United States.
  • McKibben LA; Institute for Trauma Recovery, University of North Carolina, Chapel Hill, NC, United States.
  • Arora R; Department of Anesthesiology, University of North Carolina, Chapel Hill, NC, United States.
  • Albertorio-Sáez L; Institute for Trauma Recovery, University of North Carolina, Chapel Hill, NC, United States.
  • Mickelson J; Department of Anesthesiology, University of North Carolina, Chapel Hill, NC, United States.
  • Wanstrath BJ; Institute for Trauma Recovery, University of North Carolina, Chapel Hill, NC, United States.
  • Bhatia S; Department of Anesthesiology, University of North Carolina, Chapel Hill, NC, United States.
  • Stevens JS; Institute for Trauma Recovery, University of North Carolina, Chapel Hill, NC, United States.
  • Jovanovic T; Department of Anesthesiology, University of North Carolina, Chapel Hill, NC, United States.
  • Koenen K; Institute for Trauma Recovery, University of North Carolina, Chapel Hill, NC, United States.
  • Kessler R; Department of Anesthesiology, University of North Carolina, Chapel Hill, NC, United States.
  • Ressler K; Institute for Trauma Recovery, University of North Carolina, Chapel Hill, NC, United States.
  • Beaudoin FL; Department of Anesthesiology, University of North Carolina, Chapel Hill, NC, United States.
  • McLean SA; Institute for Trauma Recovery, University of North Carolina, Chapel Hill, NC, United States.
  • Linnstaedt SD; Department of Anesthesiology, University of North Carolina, Chapel Hill, NC, United States.
Pain ; 2024 Sep 13.
Article en En | MEDLINE | ID: mdl-39287098
ABSTRACT
ABSTRACT Chronic posttraumatic pain (CPTP) is common after traumatic stress exposure (TSE) and disproportionately burdens women. We previously showed across 3 independent longitudinal cohort studies that, in women, increased peritraumatic 17ß-estradiol (E2) levels were associated with substantially lower CPTP over 1 year. Here, we assessed this relationship in a fourth longitudinal cohort and also assessed the relationship between E2 and CPTP at additional time points post-TSE. Furthermore, we used a well-validated animal model of TSE to determine whether exogenous E2 administration protects against mechanical hypersensitivity. Using nested samples and data from the Advancing Understanding of RecOvery afteR traumA study (n = 543 samples, 389 participants), an emergency department-based prospective study of TSE survivors, we assessed the relationship between circulating E2 levels and CPTP in women and men using multivariate repeated-measures mixed modeling. Male and ovariectomized female Sprague Dawley rats were exposed to TSE and administered E2 either immediately after or 3 days post-TSE. Consistent with previous results, we observed an inverse relationship between peritraumatic E2 and longitudinal CPTP in women only (ß = -0.137, P = 0.033). In animals, E2 protected against mechanical hypersensitivity in female ovariectomized rats only if administered immediately post-TSE. In conclusion, peritraumatic E2 levels, but not those at post-TSE time points, predict CPTP in women TSE survivors. Administration of E2 immediately post TSE protects against mechanical hypersensitivity in female rats. Together with previous findings, these data indicate that increased peritraumatic E2 levels in women have protective effects against CPTP development and suggest that immediate post-TSE E2 administration in women could be a promising therapeutic strategy for reducing risk of CPTP.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pain Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pain Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos