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Enhanced exploration of the mode of action of a five-layer foam dressing: critical properties to support wound healing.
Ousey, Karen; Woodmansey, Emma; Fitzgerald, Daniel J; Brownhill, Runi.
Afiliación
  • Ousey K; 1 Professor of Skin Integrity, Institute of Skin Integrity and Infection Prevention, University of Huddersfield, UK.
  • Woodmansey E; 2 Adjunct Professor, School of Nursing, Faculty of Health, Queensland University of Technology, Australia.
  • Fitzgerald DJ; 3 Visiting Professor, Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Brownhill R; 4 Clinical and Scientific Consultant, York, UK.
J Wound Care ; 33(9): 708-717, 2024 Sep 02.
Article en En | MEDLINE | ID: mdl-39287030
ABSTRACT

OBJECTIVE:

The aim of this in vitro experimental series was to explore the mode of action of a hydrocellular polyurethane foam dressing (HPFD) and how its advanced features support beneficial interactions with the wound bed to address common barriers to wound healing, thus supporting improved clinical outcomes.

METHOD:

Multiple in vitro microbiological tests were performed, assessing prevention of bacterial ingress, surface removal of bacteria, bacterial sequestration and retention into the dressing in a clinically relevant environment. Odour molecule concentrations were measured using gas chromatography and further assays explored matrix metalloproteinase (MMP)-9 retention in the dressing using enzyme linked immunosorbent assay.

RESULTS:

The HPFD demonstrated marked reductions in bioburden levels across multiple tests. These included prevention of bacterial ingress for seven days, removal of surface bacteria and absorption into the dressing. Further tests identified that most bacteria were sequestered into the hyperabsorbent layer (90.5% for Pseudomonas aeruginosa and 89.6% for meticillin-resistant Staphylococcus aureus). Moreover, the majority of bacteria (99.99% for both test organisms) were retained within the dressing, even upon compression. Additional tests demonstrated a marked reduction of odour molecules following incubation with HPFD and total retention of protease MMP-9 within the dressing.

CONCLUSIONS:

Proactive management of the wound environment with an appropriate advanced wound dressing, such as the HPFD examined in these in vitro investigations, can not only help to minimise the barriers to healing, as observed across this test series by direct interaction with the wound bed, but may, as a result, provide an ideal environment for wound progression with minimal disturbance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliuretanos / Cicatrización de Heridas Límite: Humans Idioma: En Revista: J Wound Care Asunto de la revista: ENFERMAGEM Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliuretanos / Cicatrización de Heridas Límite: Humans Idioma: En Revista: J Wound Care Asunto de la revista: ENFERMAGEM Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido