Fibroblast activation protein inhibitor positron emission tomography imaging in muscles of patients with idiopathic inflammatory myopathy.

Zhang, Yuying; Zhang, Bing; Niu, Yuanyuan; Long, Yali; He, Qiao; Luo, Guangxi; Xu, Hanshi; Zhang, Xiangsong; Zhan, Zhongping; Chen, Dongying

Zhang, Yuying; Zhang, Bing; Niu, Yuanyuan; Long, Yali; He, Qiao; Luo, Guangxi; Xu, Hanshi; Zhang, Xiangsong; Zhan, Zhongping; Chen, Dongying.

Afiliación

Zhang Y; Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Zhang B; Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Niu Y; Department of Rheumatology and Immunology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Long Y; Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
He Q; Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Luo G; Department of Rheumatology and Immunology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Xu H; Department of Rheumatology and Immunology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Zhang X; Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Zhan Z; Department of Rheumatology and Immunology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Chen D; Department of Rheumatology and Immunology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Rheumatology (Oxford) ; 2024 Sep 16.

Article en En | MEDLINE | ID: mdl-39287018

ABSTRACT

ABSTRACT

OBJECTIVES:

Mesenchymal stromal cells in muscles participate in regeneration following muscle injury. This study explored the potential of [18F]fibroblast activation protein inhibitor (FAPI)-42 positron emission tomography (PET) targeting mesenchymal stromal cells to evaluate disease activity of idiopathic inflammatory myopathy (IIM).

METHODS:

Patients with IIM (n = 26) were prospectively included and underwent [18F]FAPI-42 PET/CT and whole-body MRI between January 2023 and July 2023. Patients with malignancies were retrospectively included in the control group and only underwent [18F]FAPI-42 PET/CT (n = 28). [18F]FAPI-42 PET/CT images were evaluated using for avid-FAPI uptake and the target-to-background ratio (TBR). Whole-body MRI was evaluated for oedema, fatty infiltration, and atrophy in 42 muscles in the IIM group. The global FAPI- and MRI-derived parameters were calculated for each. PATIENT . Clinical assessment of disease activity and muscle strength were collected.

RESULTS:

Patients with IIM had significantly higher global FAPI-avid muscle ratios (0.68 [interquartile range (IQR) 0.45, 0.79] vs 0.06 [IQR 0, 0.11], p< 0.001) and global muscle TBR (2.26 [IQR 1.71, 2.75] vs 1.23 [IQR 1.02, 1.52], p< 0.001) compared with controls. In the IIM group, the median TBR was higher in muscles with oedema than in those without (2.44 [IQR 1.46, 3.27] vs 1.31 [IQR 0.95, 1.99], p< 0.001). Global FAPI-avid muscle ratios significantly correlated with global oedema score (r = 0.833), muscle strength (r=-0.649), serum creatine kinase (r = 0.456), and disease activity index (r = 0.495-0.621).

CONCLUSION:

Increased [18F]FAPI-42 uptake was associated with muscle oedema in IIM. FAPI-derived parameters correlated with IIM disease activity. [18F]FAPI-42 is a promising PET tracer for evaluating IIM disease activity.

Palabras clave

Fibroblast activation protein; MRI; Myositis; PET/CT; fibroblast activation protein inhibitor

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Rheumatology (Oxford) Asunto de la revista: REUMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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