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The causal effects of inflammatory and autoimmune skin diseases on thyroid diseases: evidence from Mendelian randomization study.
You, Ruixuan; Duan, Jiayue; Zhou, Yong; Yu, Jiangfan; Zou, Puyu; Wei, Yi; Chai, Ke; Zeng, Zhuotong; Xiao, Yangfan; Yuan, Lingqing; Xiao, Rong.
Afiliación
  • You R; Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China.
  • Duan J; Hunan Key Laboratory of Medical Epigenetics, The Second Xiangya Hospital of Central South University, Changsha, China.
  • Zhou Y; Clinical Medical Research Center for Systemic Autoimmune Diseases in Hunan Province, The Second Xiangya Hospital of Central South University, Changsha, China.
  • Yu J; Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
  • Zou P; Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha, China.
  • Wei Y; Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China.
  • Chai K; Hunan Key Laboratory of Medical Epigenetics, The Second Xiangya Hospital of Central South University, Changsha, China.
  • Zeng Z; Clinical Medical Research Center for Systemic Autoimmune Diseases in Hunan Province, The Second Xiangya Hospital of Central South University, Changsha, China.
  • Xiao Y; Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China.
  • Yuan L; Hunan Key Laboratory of Medical Epigenetics, The Second Xiangya Hospital of Central South University, Changsha, China.
  • Xiao R; Clinical Medical Research Center for Systemic Autoimmune Diseases in Hunan Province, The Second Xiangya Hospital of Central South University, Changsha, China.
Front Endocrinol (Lausanne) ; 15: 1388047, 2024.
Article en En | MEDLINE | ID: mdl-39286278
ABSTRACT

Background:

To clarify the controversy between inflammatory or autoimmune skin diseases and thyroid diseases, we performed two-sample Mendelian randomization (MR) analyses.

Participants:

Genetic data on factors associated with atopic dermatitis (AD, n=40,835), seborrheic dermatitis (SD, n=339,277), acne (n=363,927), rosacea (n=299,421), urticaria (n=374,758), psoriasis (n=373,338), psoriasis vulgaris (n=369,830), systemic lupus erythematosus (SLE, n=14,267), vitiligo (n=353,348), alopecia areata (AA, n=361,822), pemphigus (n=375,929), bullous pemphigoid (BP, n=376,274), systemic sclerosis (SSc, n=376,864), localized scleroderma (LS, n=353,449), hypothyroidism (n=314,995 or n=337,159), and hyperthyroidism (n=281,683 or n=337,159) were derived from genome-wide association summary statistics of European ancestry. Main

measures:

The inverse variance weighted method was employed to obtain the causal estimates of inflammatory or autoimmune skin diseases on the risk of thyroid diseases, complemented by MR-Egger, weighted median, and MR-pleiotropy residual sum and outlier (MR-PRESSO). Key

results:

AD, SLE, SD, and psoriasis vulgaris were associated with an increased risk of hypothyroidism, whereas BP was associated with a lower risk of hypothyroidism (all with p < 0.05). The multivariable MR analyses showed that AD (OR = 1.053; 95%CI 1.015-1.092; p = 0.006), SLE (OR = 1.093; 95%CI 1.059-1.127; p < 0.001), and SD (OR = 1.006; 95%CI 1.002-1.010; p = 0.006) independently and predominately contributed to the genetic causal effect on hypothyroidism after adjusting for smoking. The results showed no causal effects of inflammatory or autoimmune skin diseases on hyperthyroidism.

Conclusion:

The findings showed a causal effect of AD, SLE, SD on hypothyroidism, but further investigations should be conducted to explore the pathogenic mechanisms underlying these relationships.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de la Piel / Enfermedades Autoinmunes / Enfermedades de la Tiroides / Análisis de la Aleatorización Mendeliana Límite: Humans Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de la Piel / Enfermedades Autoinmunes / Enfermedades de la Tiroides / Análisis de la Aleatorización Mendeliana Límite: Humans Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza