The role of cytokines in the pathogenesis of SAPHO syndrome.

Yang, Yi; Chen, Qianzhu; Zhong, Weiyang

Yang, Yi; Chen, Qianzhu; Zhong, Weiyang.

Afiliación

Yang Y; Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Chen Q; Orthopedic Laboratory of Chongqing Medical University, Chongqing, China.
Zhong W; Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Front Immunol ; 15: 1427784, 2024.

Article en En | MEDLINE | ID: mdl-39286247

ABSTRACT

ABSTRACT

SAPHO syndrome is a complex inflammatory disorder affecting the skin and bones, characterized by osteomyelitis, acne, and pustulosis. Cytokines play a pivotal role in the pathogenesis of SAPHO syndrome, especially in inflammatory responses and immune regulation. This article reviews the cytokines involved in the pathogenesis of SAPHO syndrome, such as tumor necrosis factor α (TNF-α), interleukin 1ß (IL-1ß), IL-6, IL-10, and transforming growth factor-ß (TGF-ß), and discusses their potential as intervention points for treatment. These findings elucidate the intricate immune regulatory network of SAPHO syndrome and provide a theoretical foundation for the development of new targeted therapeutic strategies.

Asunto(s)

Síndrome de Hiperostosis Adquirido; Citocinas; Síndrome de Hiperostosis Adquirido/inmunología; Humanos; Citocinas/metabolismo; Animales

Palabras clave

IL-1ß; SAPHO syndrome; TNF-α; cytokines; immune regulation; inflammatory response

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citocinas / Síndrome de Hiperostosis Adquirido Límite: Animals / Humans Idioma: En Revista: Front Immunol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza

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