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Biocompatible WSe2@BSA Dots with Merged Catalyst and Coreactant for Efficient Electrochemiluminescence.
Yin, Fei; Zhou, Xiaohe; Zhang, Mingming; Sun, Qian; Zhao, Jinjin; Wu, Guoqiu; Zhang, Yuanjian; Shen, Yanfei.
Afiliación
  • Yin F; Medical School, Southeast University, Nanjing, 210009, China.
  • Zhou X; Medical School, Southeast University, Nanjing, 210009, China.
  • Zhang M; Center of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, China.
  • Sun Q; Medical School, Southeast University, Nanjing, 210009, China.
  • Zhao J; Clinical Laboratory, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453100, China.
  • Wu G; Center of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, China.
  • Zhang Y; Jiangsu Provincial Key Laboratory of Critical Care Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, China.
  • Shen Y; School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China.
Small ; : e2406374, 2024 Sep 17.
Article en En | MEDLINE | ID: mdl-39285809
ABSTRACT
Electrochemiluminescence (ECL) is a powerful tool for clinical diagnosis due to its exceptional sensitivity. However, the standard tripropylamine (TPrA) coreactant for Ru(bpy)3Cl2, the most widely studied and used ECL system, is highly toxic. Despite extensive research on alternative coreactants, they often fall short in poor efficiency. From a reaction kinetics perspective, accelerating electrooxidation rate of Ru(bpy)3Cl2 is an essential way to compensate the efficiency limitation of coreactants, but is rarely reported. Here, a hybrid electrocatalyst@coreactant dots for the ECL of Ru(bpy)3Cl2 is reported. The as-prepared WSe2@bovine serum albumin (WSe2@BSA) dots is biocompatible, and demonstrate dual functions, i.e., the BSA shell works as a coreactant, meanwhile, the WSe2 core effectively catalyzes Ru(bpy)3Cl2 oxidation. As a result, WSe2@BSA dots exhibit an exceptionally high efficiency comparable to TPrA for the ECL of Ru(bpy)3Cl2. In addition, the procedure for synthesizing WSe2@BSA dots is facile (room temperature, atmospheric conditions), rapid (5 min), and scalable (for millions of bioassays). A biosensor utilizing WSe2@BSA dots shows promise for highly sensitive detecting glypican-3 in clinical liver cancer serum samples, especially for alpha-fetoprotein-negative patients. This work opens a new avenue for developing a highly efficient ECL system for biosensing and clinical diagnosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Small Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Small Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania