Your browser doesn't support javascript.
loading
Investigating the shared genetic basis of inflammatory bowel disease and systemic lupus erythematosus using genetic overlap analysis.
Yuan, Weichao; Luo, Qinghua; Wu, Na.
Afiliación
  • Yuan W; Department of Anorectal Surgery, Affiliated Hospital of Jiujiang University, Jiujiang, China.
  • Luo Q; Clinical Medical College, Jiangxi University of Chinese Medicine, Nanchang, China.
  • Wu N; Clinical Medical College, Jiangxi University of Chinese Medicine, Nanchang, China. wuna0791@163.com.
BMC Genomics ; 25(1): 868, 2024 Sep 16.
Article en En | MEDLINE | ID: mdl-39285290
ABSTRACT

BACKGROUND:

Inflammatory bowel disease (IBD) and systemic lupus erythematosus (SLE) are autoimmune diseases that often coexist clinically. This phenomenon might be due to shared genetic components.

METHODS:

Genome-wide association study (GWAS) data for IBD and SLE were analyzed to determine both global and local genetic correlations using three methodologies linkage disequilibrium score regression (LDSC), genetic covariance analyzer (GNOVA), and SUPERGNOVA. The genetic overlap and risk loci were subsequently examined using the conditional/conjunctional false discovery rate (cond/conjFDR) statistical framework. Furthermore, a multi-trait analysis of MTAG was employed to validate the loci, followed by an LDSC analysis focusing on tissue-specific gene expression.

RESULTS:

GWAS findings demonstrated a marked global genetic correlation between IBD (including Crohn's disease and ulcerative colitis) and SLE. Locally, SLE showed a strong association with IBD and Crohn's disease on chromosomes 10, 19, and 22. ConjFDR analysis confirmed the genetic overlap and identified relevant genetic risk loci. MTAG further validated several shared susceptibility genes. Additionally, the LDSC-SEG analysis results indicate that IBD (including CD and UC) and SLE are jointly enriched in the tissues of Spleen and Whole Blood.

CONCLUSION:

This study confirms a genetic overlap between IBD and SLE, identifying marked comorbid genes and offering new insights for treating these diseases.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Desequilibrio de Ligamiento / Predisposición Genética a la Enfermedad / Estudio de Asociación del Genoma Completo / Lupus Eritematoso Sistémico Límite: Humans Idioma: En Revista: BMC Genomics Asunto de la revista: GENETICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Desequilibrio de Ligamiento / Predisposición Genética a la Enfermedad / Estudio de Asociación del Genoma Completo / Lupus Eritematoso Sistémico Límite: Humans Idioma: En Revista: BMC Genomics Asunto de la revista: GENETICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido