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Fundamental equations linking methylation dynamics to maximum lifespan in mammals.
Horvath, Steve; Zhang, Joshua; Haghani, Amin; Lu, Ake T; Fei, Zhe.
Afiliación
  • Horvath S; Department of Human Genetics, University of California, Los Angeles, CA, USA. shorvath@altoslabs.com.
  • Zhang J; Department of Biostatistics, University of California, Los Angeles, CA, USA. shorvath@altoslabs.com.
  • Haghani A; Altos Labs, San Diego, CA, USA. shorvath@altoslabs.com.
  • Lu AT; Department of Human Genetics, University of California, Los Angeles, CA, USA.
  • Fei Z; Department of Human Genetics, University of California, Los Angeles, CA, USA.
Nat Commun ; 15(1): 8093, 2024 Sep 16.
Article en En | MEDLINE | ID: mdl-39285199
ABSTRACT
We describe a framework that addresses concern that the rate of change in any aging biomarker displays a trivial inverse relation with maximum lifespan. We apply this framework to methylation data from the Mammalian Methylation Consortium. We study the relationship of lifespan with the average rate of change in methylation (AROCM) from two datasets one with 90 dog breeds and the other with 125 mammalian species. After examining 54 chromatin states, we conclude three key

findings:

First, a reciprocal relationship exists between the AROCM in bivalent promoter regions and maximum mammalian lifespan AROCM ∝ 1/MaxLifespan. Second, the correlation between average methylation and age bears no relation to maximum lifespan, Cor(Methyl,Age) ⊥ MaxLifespan. Third, the rate of methylation change in young animals is related to that in old animals Young animals' AROCM ∝ Old AROCM. These findings critically hinge on the chromatin context, as different results emerge in other chromatin contexts.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromatina / Regiones Promotoras Genéticas / Metilación de ADN / Longevidad / Mamíferos Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromatina / Regiones Promotoras Genéticas / Metilación de ADN / Longevidad / Mamíferos Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido