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Akkermansia muciniphila in the small intestine improves liver fibrosis in a murine liver cirrhosis model.
Oguri, Noriaki; Miyoshi, Jun; Nishinarita, Yuu; Wada, Haruka; Nemoto, Nobuki; Hibi, Noritaka; Kawamura, Naohiro; Miyoshi, Sawako; Lee, Sonny T M; Matsuura, Minoru; Osaki, Takako; Hisamatsu, Tadakazu.
Afiliación
  • Oguri N; Department of Gastroenterology and Hepatology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
  • Miyoshi J; Department of Gastroenterology and Hepatology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan. jmiyoshi@ks.kyorin-u.ac.jp.
  • Nishinarita Y; Department of Gastroenterology and Hepatology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
  • Wada H; Department of Gastroenterology and Hepatology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
  • Nemoto N; Department of Gastroenterology and Hepatology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
  • Hibi N; Department of Gastroenterology and Hepatology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
  • Kawamura N; Department of Gastroenterology and Hepatology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
  • Miyoshi S; Department of Preventive Medicine, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
  • Lee STM; Division of Biology, Kansas State University, Manhattan, KS, USA.
  • Matsuura M; Department of Gastroenterology and Hepatology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
  • Osaki T; Department of Infectious Diseases, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
  • Hisamatsu T; Department of Gastroenterology and Hepatology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan. thisamatsu@ks.kyorin-u.ac.jp.
NPJ Biofilms Microbiomes ; 10(1): 81, 2024 Sep 16.
Article en En | MEDLINE | ID: mdl-39285193
ABSTRACT
Recent evidence indicates that liver cirrhosis (LC) is a reversible condition, but there is no established intervention against liver fibrosis. Although the gut microbiota is considered involved in the pathogenesis of LC, the underlying mechanisms remain unclear. Although the antibiotic, rifaximin (RFX), is effective for hepatic encephalopathy (HE) with LC, the impact of RFX on intestinal bacteria is unknown. We investigated the bacterial compositions along the GI tract under RFX treatment using a murine LC model. RFX improved liver fibrosis and hyperammonemia and altered the bacterial composition in the small intestine. The efficacy of RFX was associated with increases in specific bacterial genera, including Akkermansia. Administration of a commensal strain of Akkermansia muciniphila improved liver fibrosis and hyperammonemia with changing bacterial composition in the small intestine. This study proposed a new concept "small intestine-liver axis" in the pathophysiology of LC and oral A. muciniphila administration is a promising microbial intervention.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Modelos Animales de Enfermedad / Microbioma Gastrointestinal / Rifaximina / Akkermansia / Intestino Delgado / Cirrosis Hepática Límite: Animals Idioma: En Revista: NPJ Biofilms Microbiomes Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Modelos Animales de Enfermedad / Microbioma Gastrointestinal / Rifaximina / Akkermansia / Intestino Delgado / Cirrosis Hepática Límite: Animals Idioma: En Revista: NPJ Biofilms Microbiomes Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos