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Development and validation of cardiometabolic risk predictive models based on LDL oxidation and candidate geromarkers from the MARK-AGE data.
Valeanu, Andrei; Margina, Denisa; Weber, Daniela; Stuetz, Wolfgang; Moreno-Villanueva, María; Dollé, Martijn E T; Jansen, Eugène Hjm; Gonos, Efstathios S; Bernhardt, Jürgen; Grubeck-Loebenstein, Beatrix; Weinberger, Birgit; Fiegl, Simone; Sikora, Ewa; Mosieniak, Grazyna; Toussaint, Olivier; Debacq-Chainiaux, Florence; Capri, Miriam; Garagnani, Paolo; Pirazzini, Chiara; Bacalini, Maria Giulia; Hervonen, Antti; Slagboom, P Eline; Talbot, Duncan; Breusing, Nicolle; Frank, Jan; Bürkle, Alexander; Franceschi, Claudio; Grune, Tilman; Gradinaru, Daniela.
Afiliación
  • Valeanu A; Carol Davila University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Traian Vuia St., 020956 Bucharest, Romania. Electronic address: andrei.valeanu@umfcd.ro.
  • Margina D; Carol Davila University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Traian Vuia St., 020956 Bucharest, Romania. Electronic address: denisa.margina@umfcd.ro.
  • Weber D; Department of Molecular Toxicology, German Institute of Human Nutrition, Potsdam-Rehbrücke, 14558 Nuthetal, Germany; NutriAct-Competence Cluster Nutrition Research Berlin-Potsdam, 14458 Nuthetal, Germany. Electronic address: Daniela.Weber@dife.de.
  • Stuetz W; Department of Food Biofunctionality, Institute of Nutritional Sciences (140), University of Hohenheim, 70599 Stuttgart, Germany. Electronic address: wolfgang.stuetz@uni-hohenheim.de.
  • Moreno-Villanueva M; Molecular Toxicology Group, Department of Biology, University of Konstanz, 78457 Konstanz, Germany; Human Performance Research Centre, Department of Sport Science, University of Konstanz, 78457 Konstanz, Germany. Electronic address: maria.moreno-villanueva@uni-konstanz.de.
  • Dollé MET; Centre for Health Protection, National Institute for Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, the Netherlands. Electronic address: Martijn.Dolle@rivm.nl.
  • Jansen EH; Centre for Health Protection, National Institute for Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, the Netherlands. Electronic address: eugenejansen99@gmail.com.
  • Gonos ES; National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, Athens, Greece. Electronic address: sgonos@eie.gr.
  • Bernhardt J; BioTeSys GmbH, Schelztorstr. 54-56, 73728 Esslingen, Germany. Electronic address: j.bernhardt@biotesys.de.
  • Grubeck-Loebenstein B; Research Institute for Biomedical Aging Research, University of Innsbruck, Rennweg, 10, 6020 Innsbruck, Austria. Electronic address: Beatrix.Grubeck-Loebenstein@uibk.ac.at.
  • Weinberger B; Research Institute for Biomedical Aging Research, University of Innsbruck, Rennweg, 10, 6020 Innsbruck, Austria. Electronic address: birgit.weinberger@uibk.ac.at.
  • Fiegl S; UMIT TIROL - Private University for Health Sciences, Medical Informatics and Technology, 6060 Hall in Tyrol, Austria. Electronic address: simone.fiegl@umit-tirol.at.
  • Sikora E; Laboratory of the Molecular Bases of Ageing, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur street, 02-093 Warsaw, Poland. Electronic address: e.sikora@nencki.edu.pl.
  • Mosieniak G; Laboratory of the Molecular Bases of Ageing, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur street, 02-093 Warsaw, Poland. Electronic address: g.mosieniak@nencki.edu.pl.
  • Toussaint O; URBC-NARILIS, University of Namur, Rue de Bruxelles, 61, Namur, Belgium.
  • Debacq-Chainiaux F; URBC-NARILIS, University of Namur, Rue de Bruxelles, 61, Namur, Belgium. Electronic address: florence.chainiaux@unamur.be.
  • Capri M; Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy; Alma Mater Research Institute on Global Challenges and Climate Change (Alma Climate), University of Bologna, 40126 Bologna, Italy. Electronic address: miriam.capri@unibo.it.
  • Garagnani P; Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. Electronic address: paolo.garagnani2@unibo.it.
  • Pirazzini C; Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy. Electronic address: chiara.pirazzini5@unibo.it.
  • Bacalini MG; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy. Electronic address: mariagiulia.bacalini@isnb.it.
  • Hervonen A; Medical School, University of Tampere, 33014 Tampere, Finland. Electronic address: antti.hervonen@gmail.com.
  • Slagboom PE; Section of Molecular Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands. Electronic address: p.slagboom@lumc.nl.
  • Talbot D; Department of Unilever Science and Technology, Beauty and Personal Care, Sharnbrook, UK. Electronic address: scoutwell.supplies@btinternet.com.
  • Breusing N; Department of Applied Nutritional Science/Dietetics, Institute of Nutritional Medicine, University of Hohenheim, Stuttgart 70599, Germany. Electronic address: nicolle_breusing@yahoo.de.
  • Frank J; Department of Food Biofunctionality, Institute of Nutritional Sciences (140), University of Hohenheim, 70599 Stuttgart, Germany. Electronic address: jan.frank@uni-hohenheim.de.
  • Bürkle A; Molecular Toxicology Group, Department of Biology, University of Konstanz, 78457 Konstanz, Germany. Electronic address: alexander.buerkle@uni-konstanz.de.
  • Franceschi C; Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy; Laboratory of Systems Medicine of Healthy Aging, Institute of Biology and Biomedicine and Institute of Information Technology, Mathematics and Mechanics, Department of Applied Math
  • Grune T; Department of Molecular Toxicology, German Institute of Human Nutrition, Potsdam-Rehbrücke, 14558 Nuthetal, Germany; NutriAct-Competence Cluster Nutrition Research Berlin-Potsdam, 14458 Nuthetal, Germany; German Center for Diabetes Research (DZD), 85764 München-Neuherberg, Germany; German Center for
  • Gradinaru D; Carol Davila University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Traian Vuia St., 020956 Bucharest, Romania; Ana Aslan National Institute of Gerontology and Geriatrics, Bucharest, Romania. Electronic address: daniela.gradinaru@umfcd.ro.
Mech Ageing Dev ; : 111987, 2024 Sep 14.
Article en En | MEDLINE | ID: mdl-39284459
ABSTRACT
The predictive value of the susceptibility to oxidation of LDL particles (LDLox) in cardiometabolic risk assessment is incompletely understood. The main objective of the current study was to assess its relationship with other relevant biomarkers and cardiometabolic risk factors from MARK-AGE data. A cross-sectional observational study was carried out on 1089 subjects (528 men and 561 women), aged 40-75 years old, randomly recruited age- and sex-stratified individuals from the general population. A correlation analysis exploring the relationships between LDLox and relevant biomarkers was undertaken, as well as the development and validation of several machine learning algorithms, for estimating the risk of the combined status of high blood pressure and obesity for the MARK-AGE subjects. The machine learning models yielded Area Under the Receiver Operating Characteristic Curve Score ranging 0.783-0.839 for the internal validation, while the external validation resulted in an Under the Receiver Operating Characteristic Curve Score between 0.648-0.787, with the variables based on LDLox reaching significant importance within the obtained predictions. The current study offers novel insights regarding the combined effects of LDL oxidation and other ageing markers on cardiometabolic risk. Future studies might be extended on larger patient cohorts, in order to obtain reproducible clinical assessment models.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mech Ageing Dev Año: 2024 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mech Ageing Dev Año: 2024 Tipo del documento: Article Pais de publicación: Irlanda