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Fabrication of a novel macrophage-targeted biomimetic delivery composite hydrogel with multiple-sensitive properties for tri-modal combination therapy of rheumatoid arthritis.
Gong, Haoyang; Hua, Yabing; Wang, Yicheng; Zhang, Xinyi; Wang, Hui; Zhao, Ziming; Zhang, Yanzhuo.
Afiliación
  • Gong H; School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China.
  • Hua Y; School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China.
  • Wang Y; School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China.
  • Zhang X; School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China.
  • Wang H; Department of Pharmacy, Xuzhou Hospital of TCM, Xuzhou 221000, China. Electronic address: xzzyywh@163.com.
  • Zhao Z; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China.
  • Zhang Y; School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China. Electronic address: yanzhuozhang@yeah.net.
Int J Pharm ; : 124708, 2024 Sep 14.
Article en En | MEDLINE | ID: mdl-39284423
ABSTRACT
In this study, a porous polydopamine (PDA) nanoparticle-decorated ß-glucan microcapsules (GMs) nanoplatform (PDA/GMs) were developed with macrophage-targeted biomimetic features and a carriers-within-carriers structure. Indocyanine green (ICG) and catalase (CAT) were subsequently co-encapsulated within the PDA/GMs to create a multifunctional nanotherapeutic agent, termed CIPGs. Furthermore, CIPGs and sinomenine (SIN) were co-loaded within a thermo-sensitive hydrogel to design an injectable delivery system, termed CIPG/SH, with potential for multi-modal therapy of rheumatoid arthritis (RA). Photothermal studies indicated that the CIPGs hold excellent photothermal conversion ability and thermal stability, as they combined the photothermal performance of both PDA and ICG. Meanwhile, the CIPGs displayed favorable oxygen self-supplying and photodynamic performance. The CIPGs showed near-infrared (NIR)-induced phototoxicity, effectively inhibiting macrophage proliferation and displaying remarkable antibacterial activity. In vitro drug release from the prepared CIPG/SH showed a controlled release pattern. Animal experiments conducted on an RA mice model confirmed that the formulated CIPG/SH exhibited significant therapeutic effects. By integrating the biological advantages, photothermal/photodynamic performance of the CIPGs, and controlled drug release performance of the thermo-sensitive hydrogels in a single delivery system, the prepared injectable CIPG/SH represents a novel versatile delivery system with great potential for multi-modal combination targeting therapy in RA.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Pharm Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Pharm Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos