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Temporary Target versus Suspended Insulin Infusion in Patients with Type 1 Diabetes Using the MiniMed 780G Advanced Closed-Loop Hybrid System During Aerobic Exercise. Randomized crossover clinical trial.
Gomez, Ana Maria; Henao-Carrillo, Diana Cristina Cristina; Muñoz Velandia, Oscar Mauricio; Romero-Alvernia, Diana Marcela; Jaramillo, Pablo; Moscoso, Evelyn; Garcia Jaramillo, Maira; Parra, Dario; Robledo, Sofia; Silva, Julio; Rondón Sepúlveda, Martin Alonso.
Afiliación
  • Gomez AM; Hospital Universitario San Ignacio, Endocrinologia, Cra 7 #40-62, Bogota, Colombia, 111021.
  • Henao-Carrillo DCC; Pontificia Universidad Javeriana, Medicine Faculty, Bogota, Colombia, 111021; anagomez@javeriana.edu.
  • Muñoz Velandia OM; Hospital Universitario San Ignacio, Endocrinology, Carrera 7 No 49 - 62, Bogota, Colombia, 110211.
  • Romero-Alvernia DM; Pontificia Universidad Javeriana, Bogota, Colombia, 110211; d-henao@javeriana.edu.co.
  • Jaramillo P; Hospital Universitario San Ignacio, Internal Medicine, Bogota, Colombia.
  • Moscoso E; Pontificia Universidad Javeriana, Bogota, Colombia; o.munoz@javeriana.edu.co.
  • Garcia Jaramillo M; Hospital Universitario San Ignacio, Bogota, Colombia.
  • Parra D; Pontificia Universidad Javeriana Facultad de Medicina, Bogota, Colombia; dmromeroalvernia@gmail.com.
  • Robledo S; Hospital Universitario San Ignacio, Bogota, Colombia.
  • Silva J; Pontificia Universidad Javeriana, Bogota, Colombia; jaramillopa@javeriana.edu.co.
  • Rondón Sepúlveda MA; Pontificia Universidad Javeriana Facultad de Medicina, Bogota, Colombia; evelyn.moscoso45@gmail.com.
Diabetes Technol Ther ; 2024 Sep 16.
Article en En | MEDLINE | ID: mdl-39284173
ABSTRACT

AIM:

To compare the safety and continuous glucose monitoring (CGM) metrics during aerobic exercise (AE) of using temporary target (TT) versus (vs.) suspension of insulin infusion (SII) in adults with type 1 diabetes (T1D) using advanced hybrid closed-loop systems.

METHODS:

Randomized crossover clinical trial. Two moderate-intensity AE sessions were performed, one with TT and one with SII. Hypoglycemic events and CGM metrics were analyzed during the immediate (baseline and 59 minutes), early (60 minutes to 6 hours), and late (6 to 36 hours) post-exercise phases.

RESULTS:

33 patients were analyzed (44.6±13.8 years, 52% male, time in range (%TIR 70-180 mg/dL) 79.4 ± 12%, time below range (%TBR) <70 and <54 mg/dL was 1.8±1.7% and 0.5±0.9%, respectively). Differences were found between TT vs. SII use in the early phase for %TIR 70-180 mg/dL (83.0 vs. 65.3,p=0.005), time in tight range (%TITR 70-140mg/dL) (56.3 vs. 41.5,p=0.04) and time above range (%TAR>180mg/dL) (15.3 vs. 31.8,p=0.01). No significant differences were found in the CGM metrics during the different phases of physical activity. When evaluating the diurnal period, %TIR was higher for TT use (82.1 vs. 73.1,p=0.02) and %TAR was higher for SII (15.0 vs. 22.96,p=0.04), with no difference in the number of hypoglycemic events or changes in time below range (%TBR) <70 and <54 mg/dL.

CONCLUSION:

The use of TT compared to SII is equally safe in the immediate, early and late phases of AE. However, the use of TT allows a better glycemic profile to be achieved in the early phase of exercise.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Diabetes Technol Ther Asunto de la revista: ENDOCRINOLOGIA / TERAPEUTICA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Diabetes Technol Ther Asunto de la revista: ENDOCRINOLOGIA / TERAPEUTICA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos