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Persistent homology reveals robustness loss in inhaled substance abuse rs-fMRI networks.
Mijangos, Martin; Pacheco, Lucero; Bravetti, Alessandro; González-García, Nadia; Padilla, Pablo; Velasco-Segura, Roberto.
Afiliación
  • Mijangos M; Instituto de Investigaciones en Matemáticas Aplicadas y en Sistemas, Universidad Nacional Autónoma de México, Mexico City, Mexico.
  • Pacheco L; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
  • Bravetti A; Instituto de Investigaciones en Matemáticas Aplicadas y en Sistemas, Universidad Nacional Autónoma de México, Mexico City, Mexico.
  • González-García N; Laboratorio de Neurociencias, Hospital Infantil de México Federico Gómez, Mexico City, Mexico.
  • Padilla P; Instituto de Investigaciones en Matemáticas Aplicadas y en Sistemas, Universidad Nacional Autónoma de México, Mexico City, Mexico.
  • Velasco-Segura R; Instituto de Ciencias Aplicadas y Tecnología, Universidad Nacional Autónoma de México, Mexico City, Mexico.
PLoS One ; 19(9): e0310165, 2024.
Article en En | MEDLINE | ID: mdl-39283839
ABSTRACT
Analyzing functional brain activity through functional magnetic resonance imaging (fMRI) is commonly done using tools from graph theory for the analysis of the correlation matrices. A drawback of these methods is that the networks must be restricted to values of the weights of the edges within certain thresholds and there is no consensus about the best choice of such thresholds. Topological data analysis (TDA) is a recently-developed tool in algebraic topology which allows us to analyze networks through combinatorial spaces obtained from them, with the advantage that all the possible thresholds can be considered at once. In this paper we applied TDA, in particular persistent homology, to study correlation matrices from rs-fMRI, and through statistical analysis, we detected significant differences between the topological structures of adolescents with inhaled substance abuse disorder (ISAD) and healthy controls. We interpreted the topological differences as indicative of a loss of robustness in the functional brain networks of the ISAD population.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Imagen por Resonancia Magnética Límite: Adolescent / Female / Humans / Male Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: México Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Imagen por Resonancia Magnética Límite: Adolescent / Female / Humans / Male Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: México Pais de publicación: Estados Unidos