Your browser doesn't support javascript.
loading
Microfluctuations in Capillary Lumens Independent of Pericyte Lining Density in the Anesthetized Mouse Cortex.
Suzuki, Hiroki; Murata, Juri; Unekawa, Miyuki; Kanno, Iwao; Izawa, Yoshikane; Tomita, Yutaka; Tanaka, Kenji F; Nakahara, Jin; Masamoto, Kazuto.
Afiliación
  • Suzuki H; Graduate School of Informatics and Engineering, University of Electro-Communications, Tokyo, Japan.
  • Murata J; Graduate School of Informatics and Engineering, University of Electro-Communications, Tokyo, Japan.
  • Unekawa M; Department of Neurology, Keio University School of Medicine, Tokyo, Japan.
  • Kanno I; Department of Functional Brain Imaging Research, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
  • Izawa Y; Department of Neurology, Keio University School of Medicine, Tokyo, Japan.
  • Tomita Y; Department of Neurology, Keio University School of Medicine, Tokyo, Japan.
  • Tanaka KF; Tomita Hospital, Nagoya, Japan.
  • Nakahara J; Division of Brain Sciences, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.
  • Masamoto K; Department of Neurology, Keio University School of Medicine, Tokyo, Japan.
Microcirculation ; : e12885, 2024 Sep 16.
Article en En | MEDLINE | ID: mdl-39283679
ABSTRACT

OBJECTIVE:

This study aimed to examine the spatiotemporal coherence of capillary lumen fluctuations in relation to spatial variations in the pericyte lining in the cortex of anesthetized mice.

METHODS:

Two-photon microscopic angiography data (previously published) were reanalyzed, and spatial variations in capillary diameter fluctuations at rest and in capillary lining with vascular mural cells were measured along capillary centerlines.

RESULTS:

Relatively large diameters of the capillaries (5.5 µm) coincided with a dense pericyte lining, while small capillaries (4.3 µm) had a sparse pericyte lining. Temporal variations had a frequency of about 0.1 Hz with an amplitude of 0.5 µm, which were negatively correlated with pericyte lining density. Spatial frequency analysis further revealed a common pattern of spatial variations in capillary diameter and pericyte lining, but temporal variations differed. The temporal variations in capillary lumens were locally distinct from those in neighboring locations, suggesting intrinsic fluctuations independent of the pericyte lining.

CONCLUSIONS:

Capillary lumens in the brain exhibit slow microfluctuations that are independent of pericyte lining. These microfluctuations could affect the distribution of flowing blood cells and may be important for homogenizing their distribution in capillary networks.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Microcirculation Asunto de la revista: ANGIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Microcirculation Asunto de la revista: ANGIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos