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The role of Perifoveal Arteriolar Tortuosity in Optical Coherence Tomography Angiography (OCTA) images as an early indicator of hypertensive retinopathy.
Park, James; Vyas, Charu; Inam, Onur; Zhou, Henry W; Snow, Zachary E; Karani, Rabia; Koenigstein, Dvir; Tezel, Tongalp H.
Afiliación
  • Park J; Department of Ophthalmology, Vagelos College of Physicians and Surgeons, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, NY, USA.
  • Vyas C; Department of Ophthalmology, Vagelos College of Physicians and Surgeons, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, NY, USA.
  • Inam O; Department of Ophthalmology, Vagelos College of Physicians and Surgeons, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, NY, USA.
  • Zhou HW; Department of Biophysics, Faculty of Medicine, Gazi University, Ankara, Turkey.
  • Snow ZE; Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA.
  • Karani R; Department of Ophthalmology, University of Miami Health System, Bascom Palmer Eye Institute, Miami, FL, USA.
  • Koenigstein D; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins Medicine, Baltimore, MD, USA.
  • Tezel TH; Department of Ophthalmology, BronxCare Health System, Bronx, NY, USA.
Graefes Arch Clin Exp Ophthalmol ; 2024 Sep 16.
Article en En | MEDLINE | ID: mdl-39283358
ABSTRACT

PURPOSE:

To assess the value of increased perifoveal retinal vascular tortuosity in optical coherence tomography angiography (OCTA) images as a biomarker of early hypertensive retinopathy and compare its clinical sensitivity and accuracy with traditional morphological changes used for Scheie classification.

METHODS:

OCTA images of 81 eyes (40 eyes from 20 hypertensive subjects and 41 eyes from 21 control subjects) were obtained retrospectively. Hypertensive retinopathy changes in randomized eyes were graded according to the Scheie classification, and perifoveal vessels were traced in a masked fashion. Tortuosity values of the perifoveal vessels were then calculated along with interobserver agreement in determining the morphometric values.

RESULTS:

There were no differences in perifoveal venular tortuosity between the hypertensive and control groups (Mean = 1.13 ± 0.04 vs. 1.13 ± 0.03), but significant differences existed for arterioles (Mean = 1.14 ± 0.05 vs. 1.11 ± 0.04). Tortuosity measurements demonstrated a significant interobserver agreement (p < 0.001), while Scheie ratings had a poor interobserver agreement (p = 0.735). There was a significant difference in Scheie classification between the hypertensive and control groups (Mean = 1.06 ± 0.54 vs. 0.50 ± 0.43, p = 0.005).

CONCLUSIONS:

OCTA-based perifoveal retinal arteriolar tortuosity may be a potential reliable biomarker with certain advantages for detecting early hypertensive retinopathy than morphological changes used for the Scheie classification. This may have broad applications and establish important parameters in utilizing OCTA for screening protocols, considering the importance of early detection of systemic hypertension.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Graefes Arch Clin Exp Ophthalmol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Graefes Arch Clin Exp Ophthalmol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania