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Modulation of Melanocyte in Melasma Patients After Picosecond Laser Treatment.
Chen, Ching-Li; Chen, Chih-Chiang; Tsai, Feng-Ling; Chen, I-Ling; Huang, Ling; Yen, Yu-Chun; Hwang, Chian-Yaw.
Afiliación
  • Chen CL; Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan.
  • Chen CC; Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
  • Tsai FL; Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan.
  • Chen IL; Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
  • Huang L; Department of Dermatology, National Yang Ming Chiao Tung University, Taipei, Taiwan.
  • Yen YC; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
  • Hwang CY; Apollo Medical Optics, Ltd, Taipei, Taiwan.
J Cosmet Dermatol ; 2024 Sep 16.
Article en En | MEDLINE | ID: mdl-39282999
ABSTRACT

BACKGROUND:

Melasma is a therapeutically challenging hyperpigmented skin condition. Currently, there is a lack of in vivo observation regarding changes in melanin and dendritic melanocytes after laser treatment.

OBJECTIVE:

To investigate alterations in melanin and melanocytes in melasma before and after laser treatment using optical coherence tomography (OCT).

METHODS:

Eight female melasma patients were enrolled in Taiwan. Based on the baseline OCT scans, the patients were categorized into either epidermal-type or mixed-type melasma and were assigned different treatment protocols accordingly. Sequential OCT images were collected from melasma lesions and normal skin at baseline, Week 4 and Week 8.

RESULTS:

After 8 weeks of laser treatment, the mean Melasma Area Severity Index (MASI) score improved from 10.92 to 6.30. Results from OCT showed no significant changes in the normalized density, area, or intensity of melanin in both lesional and normal skin. At baseline, the mean length of dendritic melanocytes in the affected skin was 15% longer than those in normal skin; at Week 8, the mean length of lesional dendritic melanocytes became the same as those in normal skin. Additionally, the mean width of dendritic melanocytes decreased from being 4% wider to only 2% wider than those in normal skin.

CONCLUSION:

After 8 weeks of treatment, an improvement of MASI score was noted, mainly attributable to a reduction in lesional area. OCT showed no notable change regarding melanin, but a decrease in length and width of dendritic melanocytes was noted in the lesional skin of melasma patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Cosmet Dermatol Asunto de la revista: DERMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Cosmet Dermatol Asunto de la revista: DERMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido