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Inflammatory protein associations with brain MRI measures: Framingham Offspring Cohort.
Chen, Jiachen; Ragab, Ahmed A Y; Doyle, Margaret F; Alosco, Michael L; Fang, Yuan; Mez, Jesse; Satizabal, Claudia L; Qiu, Wei Qiao; Murabito, Joanne M; Lunetta, Kathryn L.
Afiliación
  • Chen J; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
  • Ragab AAY; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
  • Doyle MF; Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
  • Alosco ML; Boston University Chobanian & Avedisian School of Medicine, Boston University Alzheimer's Disease Research Center and CTE Center, Boston, Massachusetts, USA.
  • Fang Y; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
  • Mez J; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, State University of New York, Binghamton, New York, USA.
  • Satizabal CL; Boston University Chobanian & Avedisian School of Medicine, Boston University Alzheimer's Disease Research Center and CTE Center, Boston, Massachusetts, USA.
  • Qiu WQ; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
  • Murabito JM; Framingham Heart Study, National Heart, Lung, and Blood Institute and Boston University School of Medicine, Framingham, Massachusetts, USA.
  • Lunetta KL; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Alzheimers Dement ; 2024 Sep 16.
Article en En | MEDLINE | ID: mdl-39282876
ABSTRACT

INTRODUCTION:

Brain magnetic resonance imaging (MRI) and inflammatory biomarkers are crucial for investigating preclinical neurocognitive disorders. Current investigations focus on a few inflammatory markers. The study aims to investigate the associations between inflammatory biomarkers and MRI measures and to examine sex differences among the associations in the Framingham Heart Study.

METHODS:

Dementia and stroke-free participants underwent OLINK Proteomics profiling and MRI measurements within 5 years. Pairwise cross-sectional analysis assessed 68 biomarkers with 13 brain MRI volumes, adjusting for covariates and familial correlations.

RESULTS:

Elevated CDCP1, IL6, OPG, and 4E.BP1 were related to smaller total cerebral brain volume (TCBV), whereas higher HGF, IL8, and MMP10 were associated with smaller TCBV, total and frontal white matter volumes. Higher SCF and TWEAK were associated with larger TCBV. In sex-stratified analyses, associations were observed exclusively among males.

DISCUSSION:

We report several associations between inflammatory biomarkers and brain volumes, highlighting different associations within sex subgroups. HIGHLIGHTS Higher CDCP1, IL6, OPG, and 4E.BP1 levels were associated with smaller TCBV. Higher levels of HGF, IL8 and MMP10 were associated with smaller TCBV, CWV and FWV. Higher levels of SCF and TWEAK, were associated with larger TCBV. Significance diminished in models adjusting for CVD risk factors. Associations were observed exclusively in males.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Alzheimers Dement Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Alzheimers Dement Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos