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Effect of body size on the oral pharmacokinetics of oxytetracycline in rainbow trout (Oncorhynchus mykiss).
Corum, Orhan; Turk, Erdinc; Durna Corum, Duygu; Terzi, Ertugrul; Cellat, Mustafa; Yildirim, Önder; Uney, Kamil.
Afiliación
  • Corum O; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay, Türkiye.
  • Turk E; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay, Türkiye.
  • Durna Corum D; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay, Türkiye.
  • Terzi E; Department of Veterinary Medicine, Devrekani TOBB Vocational School, University of Kastamonu, Kastamonu, Türkiye.
  • Cellat M; Department of Physiology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay, Türkiye.
  • Yildirim Ö; Fisheries Faculty, Mugla University, Mugla, Türkiye.
  • Uney K; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, Konya, Türkiye.
PeerJ ; 12: e17973, 2024.
Article en En | MEDLINE | ID: mdl-39282114
ABSTRACT

Objective:

The aim of this study was to determine the plasma pharmacokinetics of oxytetracycline (OTC) in rainbow trout (Oncorhynchus mykiss) of different body sizes.

Methods:

The research was carried out on three groups as small (30-50 g), medium (90-110 g) and large (185-215 g) body sizes at 8 ± 0.5 °C. OTC was administered orally at a dose of 60 mg/kg to all groups. Blood samples were taken at 19 different sampling times until the 384 h after oxytetracycline administration. The plasma concentrations of OTC were measured using high pressure liquid chromatography-ultraviolet and pharmacokinetic parameters were evaluated using non-compartmental analysis.

Results:

OTC was detected in small-body sized fish until the 336 h and in medium and large-body sized fish until the 384 h. The elimination half-life of OTC was 85.46, 87.24 and 86.98 h in the small, medium and large body size groups, respectively. The peak plasma concentration increased from 0.66 to 1.11 µg/mL, and the area under the plasma concentration-versus time curve from zero (0) h to infinity (∞) increased from 87.86 to 151.52 h*µg/mL, in tandem with the increase in fish body size. As fish body size increased, volume of distribution and total body clearance decreased.

Conclusion:

These results show that the pharmacokinetics of OTC vary depending on fish size. Therefore, there is a need to reveal the pharmacodynamic activity of OTC in rainbow trout of different body sizes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxitetraciclina / Oncorhynchus mykiss / Tamaño Corporal / Antibacterianos Límite: Animals Idioma: En Revista: PeerJ Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxitetraciclina / Oncorhynchus mykiss / Tamaño Corporal / Antibacterianos Límite: Animals Idioma: En Revista: PeerJ Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos