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TGF-ß1 overexpression in severe COVID-19 survivors and its implications for early-phase fibrotic abnormalities and long-term functional impairment.
Alfaro, Enrique; Casitas, Raquel; Díaz-García, Elena; García-Tovar, Sara; Galera, Raúl; Torres-Vargas, María; Fernández-Velilla, María; López-Fernández, Cristina; Añón, José M; Quintana-Díaz, Manuel; García-Río, Francisco; Cubillos-Zapata, Carolina.
Afiliación
  • Alfaro E; Respiratory Diseases Group, Respiratory Service, La Paz University Hospital, IdiPAZ, Madrid, Spain.
  • Casitas R; Biomedical Research Networking Centre on Respiratory Diseases (CIBERES), Madrid, Spain.
  • Díaz-García E; Respiratory Diseases Group, Respiratory Service, La Paz University Hospital, IdiPAZ, Madrid, Spain.
  • García-Tovar S; Biomedical Research Networking Centre on Respiratory Diseases (CIBERES), Madrid, Spain.
  • Galera R; Respiratory Diseases Group, Respiratory Service, La Paz University Hospital, IdiPAZ, Madrid, Spain.
  • Torres-Vargas M; Biomedical Research Networking Centre on Respiratory Diseases (CIBERES), Madrid, Spain.
  • Fernández-Velilla M; Respiratory Diseases Group, Respiratory Service, La Paz University Hospital, IdiPAZ, Madrid, Spain.
  • López-Fernández C; Respiratory Diseases Group, Respiratory Service, La Paz University Hospital, IdiPAZ, Madrid, Spain.
  • Añón JM; Biomedical Research Networking Centre on Respiratory Diseases (CIBERES), Madrid, Spain.
  • Quintana-Díaz M; Respiratory Diseases Group, Respiratory Service, La Paz University Hospital, IdiPAZ, Madrid, Spain.
  • García-Río F; Biomedical Research Networking Centre on Respiratory Diseases (CIBERES), Madrid, Spain.
  • Cubillos-Zapata C; Department of Intensive Medicine, La Paz University Hospital, Madrid, Spain.
Front Immunol ; 15: 1401015, 2024.
Article en En | MEDLINE | ID: mdl-39281687
ABSTRACT

Introduction:

In post-COVID survivors, transforming growth factor-beta-1 (TGF-ß1) might mediate fibroblast activation, resulting in persistent fibrosis.

Methods:

In this study, 82 survivors of COVID-19-associated ARDS were examined at 6- and 24-months post-ICU discharge. At 6-months, quantitative CT analysis of lung attenuation was performed and active TGF-ß1 was measured in blood and exhaled breath condensate (EBC).

Results:

At 6-months of ICU-discharge, patients with reduced DmCO/alveolar volume ratio exhibited higher plasma and EBC levels of active TGF-ß1. Plasma TGF-ß1 levels were elevated in dyspneic survivors and directly related to the high-attenuation lung volume. In vitro, plasma and EBC from survivors induced profibrotic changes in human primary fibroblasts in a TGF-ß receptor-dependent manner. Finally, at 6-months, plasma and EBC active TGF-ß1 levels discriminated patients who, 24-months post-ICU-discharge, developed gas exchange impairment.

Discussion:

TGF-ß1 pathway plays a pivotal role in the early-phase fibrotic abnormalities in COVID-19-induced ARDS survivors, with significant implications for long-term functional impairment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sobrevivientes / Factor de Crecimiento Transformador beta1 / SARS-CoV-2 / COVID-19 Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Front Immunol Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sobrevivientes / Factor de Crecimiento Transformador beta1 / SARS-CoV-2 / COVID-19 Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Front Immunol Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza