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Lipids from a snail host regulate the multicellular behavior of a predator of parasitic schistosomes.
Kidner, Ria Q; Goldstone, Eleanor B; Laidemitt, Martina R; Sanchez, Melissa C; Gerdt, Catherine; Brokaw, Lorin P; Ros-Rocher, Núria; Morris, Jamie; Davidson, W Sean; Gerdt, Joseph P.
Afiliación
  • Kidner RQ; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA.
  • Goldstone EB; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA.
  • Laidemitt MR; Department of Biology, Center for Evolutionary and Theoretical Immunology, Parasite Division, Museum of Southwestern Biology, University of New Mexico, Albuquerque, NM 87131, USA.
  • Sanchez MC; Department of Biology, Center for Evolutionary and Theoretical Immunology, Parasite Division, Museum of Southwestern Biology, University of New Mexico, Albuquerque, NM 87131, USA.
  • Gerdt C; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA.
  • Brokaw LP; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA.
  • Ros-Rocher N; Department of Cell Biology and Infection and Department of Developmental and Stem Cell Biology, Institut Pasteur, Université Paris-Cité, CNRS UMR3691, 25-28 Rue du Docteur Roux, 75015 Paris, France.
  • Morris J; Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati OH 45237, USA.
  • Davidson WS; Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati OH 45237, USA.
  • Gerdt JP; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA.
iScience ; 27(9): 110724, 2024 Sep 20.
Article en En | MEDLINE | ID: mdl-39280608
ABSTRACT
Transmission of vector-borne diseases can be slowed by symbionts within the secondary hosts that spread disease. Snails spread schistosomiasis, and the snail symbiont Capsaspora owczarzaki kills schistosome larvae. In studying how Capsaspora colonizes its host snail, we discovered that Capsaspora responded to its host by forming multicellular aggregates. We elucidated the chemical cue for aggregation hemolymph phosphatidylcholines (PCs). Furthermore, we uncovered that Capsaspora cells aggregate to different degrees in sera from different host snails-and these responses correlate with serum concentrations of PCs. Therefore, Capsaspora senses a host factor that can indicate the identity and physiological state of its host. Since cellular aggregation controls microbial motility, feeding, and immune evasion, this response within host tissue may be important for colonization. If so, snail serum PC and Capsaspora aggregation will be molecular and cellular markers to discern which conditions will favor the colonization of snails (and potential exclusion of schistosomes) by Capsaspora.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: IScience Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: IScience Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos