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Implementation of Cone Beam Computed Tomography-Guided Online Adaptive Radiotherapy for Challenging Trimodal Therapy in Bladder Preservation: A Report of Two Cases.
Jain, Samyak; Peterson, John S; Semenenko, Vladimir; Redler, Gage; Grass, G Daniel.
Afiliación
  • Jain S; College of Medicine, University of South Florida, Tampa, USA.
  • Peterson JS; Department of Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, USA.
  • Semenenko V; Department of Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, USA.
  • Redler G; Department of Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, USA.
  • Grass GD; Department of Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, USA.
Cureus ; 16(8): e66993, 2024 Aug.
Article en En | MEDLINE | ID: mdl-39280408
ABSTRACT
Muscle invasive bladder cancer (MIBC) is an aggressive disease with a high risk of metastasis. Bladder preservation with trimodality therapy (TMT) is an option for well-selected patients or poor cystectomy candidates. Cone beam computed tomography (CBCT)-guided online adaptive radiotherapy (oART) shows promise in improving the dose to treatment targets while better sparing organs at risk (OARs). The following series presents two cases in which the capabilities of a CBCT-guided oART platform were leveraged to meet clinical challenges. The first case describes a patient with synchronous MIBC and high-risk prostate cancer with challenging target-OAR interfaces. The second recounts the case of a patient with a history of low dose rate (LDR) brachytherapy to the prostate who was later diagnosed with MIBC and successfully treated with CBCT-guided oART with reduced high-dose volume bladder targeting. To date, both patients report minimal side effects and are without disease recurrence. These cases illustrate how CBCT-guided online adaptive systems may efficiently aid radiation oncologists in treating patients with more complex clinical scenarios who desire bladder-sparing therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cureus Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cureus Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos