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Impact of Magnesium Supplementation on Blood Pressure: An Umbrella Meta-Analysis of Randomized Controlled Trials.
Alharran, Abdullah M; Alzayed, Mooza M; Jamilian, Parsa; Prabahar, Kousalya; Kamal, Aminah Hassan; Alotaibi, Muteb N; Elshaer, Omar E; Alhatm, Mshal; Masmoum, Mohd Diya; Hernández-Wolters, Benjamin; Sindi, Raghad; Kord-Varkaneh, Hamed; Abu-Zaid, Ahmed.
Afiliación
  • Alharran AM; College of Medicine & Medical Sciences, Arabian Gulf University, Manama, Bahrain.
  • Alzayed MM; College of Medicine & Medical Sciences, Arabian Gulf University, Manama, Bahrain.
  • Jamilian P; School of Medicine, Keele University, Staffordshire, United Kingdom.
  • Prabahar K; Department of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.
  • Kamal AH; Department of Adult Cardiology, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.
  • Alotaibi MN; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
  • Elshaer OE; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
  • Alhatm M; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
  • Masmoum MD; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
  • Hernández-Wolters B; University Center for Health Science, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
  • Sindi R; Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
  • Kord-Varkaneh H; Department of Nutrition and Food Hygiene, School of Medicine, Nutrition Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Abu-Zaid A; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Curr Ther Res Clin Exp ; 101: 100755, 2024.
Article en En | MEDLINE | ID: mdl-39280209
ABSTRACT
Background and

aim:

Conflicting results on the effect of magnesium supplementation on blood pressure have been published in previous meta-analyses; hence, we conducted this umbrella meta-analysis of RCTs to provide a more robust conclusion on its effects.

Methods:

Four databases including PubMed, Scopus, EMBASE, and Web of Science were searched to find pertinent papers published on international scientific from inception up to July 15, 2024. We utilized STATA version 17.0 to carry out all statistical analyses (Stata Corporation, College Station, TX, US). The random effects model was used to calculate the overall effect size ES and CI.

Findings:

Ten eligible review papers with 8610 participants studied the influence of magnesium on SBP and DBP. The pooling of their effect sizes resulted in a significant reduction of SBP (ES = -1.25 mmHg; 95% CI -1.98, -0.51, P = 0.001) and DBP (ES = -1.40 mmHg; 95% CI -2.04, -0.75, P = 0.000) by magnesium supplementation. In subgroup analysis, a significant reduction in SBP and DBP was observed in magnesium intervention with dosage ≥400 mg/day (ES for SBP = -6.38 mmHg; ES for DBP = -3.71mmHg), as well as in studies with a treatment duration of ≥12 weeks (ES for SBP = -0.42 mmHg; ES for DBP = -0.45 mmHg). Implications The findings of the present umbrella meta-analysis showed an overall decrease of SBP and DBP with magnesium supplementation, particularly at doses of ≥400 mg/day for ≥12 weeks.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Ther Res Clin Exp Año: 2024 Tipo del documento: Article País de afiliación: Bahrein Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Ther Res Clin Exp Año: 2024 Tipo del documento: Article País de afiliación: Bahrein Pais de publicación: Estados Unidos