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PTCOG international survey of practice patterns and trends in utilization of proton therapy for breast cancer.
Choi, J Isabelle; Hardy-Abeloos, Camille; Lozano, Alicia; Hanlon, Alexandra; Vargas, Carlos; Maduro, John H; Bradley, Julie; Offersen, Birgitte; Haffty, Bruce; Pankuch, Mark; Amos, Richard; Kim, Nalee; MacDonald, Shannon M; Kirova, Youlia; Mutter, Robert W.
Afiliación
  • Choi JI; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Hardy-Abeloos C; New York Proton Center, New York, NY, USA.
  • Lozano A; Department of Radiation Oncology, NYU Langone, New York, NY, USA.
  • Hanlon A; Center for Biostatistics and Health Data Science, Department of Statistics, Virginia Tech, Roanoke, VA, USA.
  • Vargas C; Center for Biostatistics and Health Data Science, Department of Statistics, Virginia Tech, Roanoke, VA, USA.
  • Maduro JH; Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ, USA.
  • Bradley J; Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Offersen B; Department of Radiation Oncology, University of Florida, Jacksonville, FL, USA.
  • Haffty B; Dept of Experimental Clinical Oncology, Dept Oncology, Danish Centre for Particle Therapy, Aarhus University Hospital, Denmark.
  • Pankuch M; Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
  • Amos R; Department of Medical Physics, Northwestern Medicine Proton Center, Warrenville, IL, USA.
  • Kim N; Department of Medical Physics & Biomedical Engineering, University College London, London, UK.
  • MacDonald SM; Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
  • Kirova Y; Department of Radiation Oncology, Mass General Brigham, Boston, MA, USA.
  • Mutter RW; Department of Radiation Oncology, Institut Curie, Paris, France.
Clin Transl Radiat Oncol ; 48: 100847, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39280125
ABSTRACT
Purpose/

objectives:

The indications, techniques, and extent to which proton beam therapy (PBT) is employed for breast cancer are unknown. We seek to determine PBT utilization for breast cancer. Materials/

methods:

The Particle Therapy Co-Operative Group (PTCOG) Breast Subcommittee developed an IRB-approved 29-question survey and sent it to breast cancer radiation oncologists at all active PBT centers worldwide in June 2023. Descriptive statistics were used to summarize responses, and comparisons by continent were performed using Fisher's exact tests.

Results:

Of 79 surveys distributed, 28 recipients submitted responses (35 % response rate) representing fifteen U.S., 8 European, and 5 Asian centers (continent response rate 50 %, 38 %, and 18 %, respectively). Overall, 93 % reported treating breast cancer patients with PBT; 13 (50 %) have treated ≥100 breast cancer patients at their center since opening. Most (89 %) have pencil beam scanning technology. Nearly half (46 %) use moderate hypofractionation (15-20 fractions) for regional nodal irradiation and 42 % conventional fractionation (25-30 fractions). More European centers prefer hypofractionation (88 %) vs. Asian (50 %) and U.S. (21 %) centers (p = 0.003). Common patient selection methods were practitioner determination/patient preference (n = 16) and comparative plan evaluation (n = 15). U.S. centers reported the most experience with breast PBT, with 71 % having treated ≥100 breast cancer patients vs. 38 % in Europe and none in Asia (p = 0.001). Of respondent centers, 39 % enrolled ≥75 % of breast PBT patients on a research study.

Conclusion:

Utilization, patient selection methods, and dose-fractionation approaches for breast cancer PBT vary worldwide. These survey data serve as a benchmark from which successor surveys can provide insight on practice pattern evolution.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Clin Transl Radiat Oncol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Irlanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Clin Transl Radiat Oncol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Irlanda