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Magnetic stirring with iron oxide nanospinners accretes neurotoxic Aß42 oligomers into phagocytic clearable plaques for Alzheimer's disease treatment.
Sabu, Arjun; Huang, Yu Ching; Sharmila, Ramalingam; Sun, Chih-Yuan; Shen, Min-Ying; Chiu, Hsin-Cheng.
Afiliación
  • Sabu A; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu City, Taiwan.
  • Huang YC; Department of Neurology, Taoyuan General Hospital, Ministry of Health and Welfare, Taiwan.
  • Sharmila R; Department of Industrial Engineering and Management, Yuan-Ze University, Taoyuan City 320315 Taiwan.
  • Sun CY; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu City, Taiwan.
  • Shen MY; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu City, Taiwan.
  • Chiu HC; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu City, Taiwan.
Mater Today Bio ; 28: 101213, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39280110
ABSTRACT
An increasing number of medications have been explored to treat the progressive and irreversible Alzheimer's disease (AD) that stands as the predominant form of dementia among neurodegenerative ailments. However, assertions about toxic side effects of these drugs are a significant hurdle to overcome, calling for drug-free nanotherapeutics. Herein, a new therapeutic strategy devoid of conventional drugs or other cytotoxic species was developed. The constructed superparamagnetic iron oxide nanoparticles (SPIONs) nanospinners can accrete neurotoxic ß-amyloid 42 oligomers (oAß42) into aggregated magnetic plaques (mpAß) by mechanical rotating force via remote interaction between nanoparticles and the applied magnetic field. While the cellular uptake of mpAß attained from the magnetic stirring treatment by neuronal cells is severely limited, the facile phagocytic uptake of mpAß by microglial cells leads to the polarization of the brain macrophages to M2 phenotype and thus the increased anti-inflammatory responses to the treatment. The SPION stirring treatment protects the AD mice from memory deterioration and maintain cognitive ability as evidenced from both nesting and Barnes maze tests. The examination of the oAß42 injected brain tissues with the stirring treatment showed significant amelioration of functional impairment of neurons, microglia, astrocytes and oligodendrocytes alongside no obvious tissue damage caused by stirring meanwhile complete degradation of SPION was observed at day 7 after the treatment. The in vitro and animal data of this work strongly corroborate that this new modality of undruggable stirring treatment with SPIONs provides a new feasible strategy for developing novel AD treatments.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mater Today Bio Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mater Today Bio Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido