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Causal role of gut microbiota, serum metabolites, immunophenotypes in myocarditis: a mendelian randomization study.
Li, Kaiyuan; Liu, Peng; Wang, Xiuqi; Zheng, Zhipeng; Liu, Miao; Ye, Jun; Zhu, Li.
Afiliación
  • Li K; Graduate School of Dalian Medical University, Dalian Medical University, Dalian, China.
  • Liu P; Department of Cardiovascular Medicine, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, China.
  • Wang X; Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
  • Zheng Z; Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
  • Liu M; Graduate School of Dalian Medical University, Dalian Medical University, Dalian, China.
  • Ye J; Department of Cardiovascular Medicine, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, China.
  • Zhu L; Department of Cardiovascular Medicine, Center Hospital of Shandong First Medical University, Jinan, China.
Front Genet ; 15: 1382502, 2024.
Article en En | MEDLINE | ID: mdl-39280093
ABSTRACT

Background:

The intricate relationship among gut microbiota, serum metabolites, and immunophenotypes may significantly impact myocarditis. However, direct causal links between these domains and myocarditis are not well understood.

Methods:

The study performed Mendelian randomization (MR) analysis using genetic data from public sources. Exposure data included 211 gut microbiota, 486 serum metabolites, and 731 immunophenotypes from Mibiogen, the Metabolomics GWAS server, and GWAS catalog databases. Single nucleotide polymorphisms (SNPs) were selected as instrumental variables based on established criteria. Myocarditis data from GWAS (427,911 participants, 24, 180, 570 SNPs) were used as the outcome variable. MR analysis was conducted using Inverse Variance Weighting (IVW), with Cochran's Q test for heterogeneity and Egger's intercept to assess horizontal pleiotropy.

Results:

9 gut microbiota, 10 serum metabolites, and 2 immunophenotypes were negatively associated with myocarditis risk. In contrast, 5 gut microbiota, 12 serum metabolites, and 7 immunophenotypes were positively associated with myocarditis risk (all, P < 0.05). Sensitivity analyses confirmed the stability of these results.

Conclusion:

This MR study suggests that gut microbiota, serum metabolites, and immunophenotypes may causally influence myocarditis risk. These findings provide genetic evidence for myocarditis etiology and could inform future precision prevention and treatment strategies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Genet Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Genet Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza