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Concomitant or antecedent intraductal papillary mucinous neoplasm is not a prognostic factor in resected pancreatic cancer.
Uson Junior, Pedro Luiz Serrano; Nagy, Ana Luiza Spina; Dias, Igor Wanderley Reis; de Rezende, Marcelo Bruno; Pestana, Roberto; Bugano, Diogo; Tustumi, Francisco; Namur, Guilherme Naccache; Kruger, Jaime Arthur Pirola; Goldenberg, Alberto; Araujo, Sergio Eduardo Alonso; Kim, Nam Jin; Klajner, Sidney; Borad, Mitesh; Moura, Fernando.
Afiliación
  • Uson Junior PLS; Center for Personalized Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.
  • Nagy ALS; Mayo Clinic Cancer Center, Phoenix, AZ, USA.
  • Dias IWR; Department of Oncology, Hospital do Coração (HCOR), Sao Paulo, Brazil.
  • de Rezende MB; Center for Personalized Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.
  • Pestana R; Center for Personalized Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.
  • Bugano D; Center for Personalized Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.
  • Tustumi F; Center for Personalized Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.
  • Namur GN; Center for Personalized Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.
  • Kruger JAP; Center for Personalized Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.
  • Goldenberg A; Center for Personalized Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.
  • Araujo SEA; Center for Personalized Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.
  • Kim NJ; Center for Personalized Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.
  • Klajner S; Center for Personalized Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.
  • Borad M; Center for Personalized Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.
  • Moura F; Center for Personalized Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.
J Gastrointest Oncol ; 15(4): 1820-1826, 2024 Aug 31.
Article en En | MEDLINE | ID: mdl-39279955
ABSTRACT

Background:

Intraductal papillary mucinous neoplasm (IPMN)-associated pancreatic cancer is becoming a common subtype of pancreatic cancer found in resected specimens. The prognostic of this subtype is still under evaluation. The study aims to evaluate the prognosis of IPMN-associated pancreatic adenocarcinoma compared to the conventional pancreatic adenocarcinoma.

Methods:

In this study, patients with resected pancreatic neoplasms and IPMN treated at Hospital Israelita Albert Einstein, from January 2016 to December 2020, were analyzed. Overall survival (OS) was estimated using the Kaplan-Meier method, and correlations between the variables of interest and the disease specific OS was assessed by multivariate analysis.

Results:

Of 187 patients undergoing resection for pancreatic adenocarcinoma or IPMN, 125 (67%) had pancreatic adenocarcinoma, 33 (18%) had IPMN-associated pancreatic adenocarcinoma, and 29 (16%) had IPMN. Resected IPMN was associated with long-term OS for most of the patients. Similar OS was identified in this study in upfront resected pancreatic cancer associated or not with IPMN. No statistical differences in median OS were identified between resected pancreatic adenocarcinoma and IPMN-associated pancreatic adenocarcinoma (48 vs. 44 months, P=0.44). Size of the tumor [hazard ratio (HR), 1.33], resected stage III (HR, 1.31), perineural invasion (HR, 1.58), lymphovascular invasion (HR, 1.44), positive lymph nodes (HR, 1.34), and neoadjuvant treatment (HR, 1.70) were associated with worse outcomes.

Conclusions:

Our findings confirm that resected pancreatic cancer has a poor prognosis and IPMN-associated pancreatic adenocarcinoma has the same prognosis as a conventional pancreatic adenocarcinoma. More than half of the cases of IPMN-associated adenocarcinoma already had positive lymph nodes. The impact of neoadjuvant treatment in this group of patients should be investigated in larger cohorts.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Gastrointest Oncol Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Gastrointest Oncol Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: China