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MBV-Pipe: A One-Stop Toolbox for Assessing Mouse Brain Morphological Changes for Cross-Scale Studies.
Jiang, Wentao; Liu, Xinyi; Song, Ming; Yang, Zhengyi; Sun, Lan; Jiang, Tianzi.
Afiliación
  • Jiang W; Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
  • Liu X; School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Song M; Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
  • Yang Z; Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China. msong@nlpr.ia.ac.cn.
  • Sun L; Xiaoxiang Institute for Brain Health and Yongzhou Central Hospital, Yongzhou, 425000, China. msong@nlpr.ia.ac.cn.
  • Jiang T; Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
Neuroinformatics ; 2024 Sep 16.
Article en En | MEDLINE | ID: mdl-39278985
ABSTRACT
Mouse models are crucial for neuroscience research, yet discrepancies arise between macro- and meso-scales due to sample preparation altering brain morphology. The absence of an accessible toolbox for magnetic resonance imaging (MRI) data processing presents a challenge for assessing morphological changes in the mouse brain. To address this, we developed the MBV-Pipe (Mouse Brain Volumetric Statistics-Pipeline) toolbox, integrating the methods of Diffeomorphic Anatomical Registration Through Exponentiated Lie Algebra (DARTEL)-Voxel-based morphometry (VBM) and Tract-Based Spatial Statistics (TBSS) to evaluate brain tissue volume and white matter integrity. To validate the reliability of MBV-Pipe, brain MRI data from seven mice at three time points (in vivo, post-perfusion, and post-fixation) were acquired using a 9.4T ultra-high MRI system. Employing the MBV-Pipe toolbox, we discerned substantial volumetric changes in the mouse brain following perfusion relative to the in vivo condition, with the fixation process inducing only negligible variations. Importantly, the white matter integrity was found to be largely stable throughout the sample preparation procedures. The MBV-Pipe source code is publicly available and includes a user-friendly GUI for facilitating quality control and experimental protocol optimization, which holds promise for advancing mouse brain research in the future.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Neuroinformatics Asunto de la revista: INFORMATICA MEDICA / NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Neuroinformatics Asunto de la revista: INFORMATICA MEDICA / NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos