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Role of B cells in intratumoral MBTA immunotherapy of murine pheochromocytoma model.
Uher, Ondrej; Hadrava Vanova, Katerina; Petrlakova, Katerina; Labitt, Rachael; Lencova, Radka; Frejlachova, Andrea; Ye, Juan; Wang, Herui; Masarik, Michal; Zenka, Jan; Zhuang, Zhengping; Pacak, Karel.
Afiliación
  • Uher O; Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda 20892, MD, USA. Electronic address: ondrej.uher@nih.gov.
  • Hadrava Vanova K; Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda 20892, MD, USA. Electronic address: katerina.hadravavanova@nih.gov.
  • Petrlakova K; Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda 20892, MD, USA; Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno 62500 Czech Republic. Electronic address: katerina.petrlakova@med
  • Labitt R; Research Animal Management Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda 20892, MD, USA. Electronic address: rachael.labitt@nih.gov.
  • Lencova R; Department of Medical Biology, Faculty of Science, University of South Bohemia, Ceske Budejovice 37005, Czech Republic. Electronic address: lencor00@prf.jcu.cz.
  • Frejlachova A; Department of Medical Biology, Faculty of Science, University of South Bohemia, Ceske Budejovice 37005, Czech Republic. Electronic address: frejla00@prf.jcu.cz.
  • Ye J; Neuro-Oncology Branch, National Cancer Institute, NIH, Bethesda 20892, MD, USA. Electronic address: juan.ye@nih.gov.
  • Wang H; Neuro-Oncology Branch, National Cancer Institute, NIH, Bethesda 20892, MD, USA. Electronic address: herui.wang@nih.gov.
  • Masarik M; Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno 62500 Czech Republic; Department of Physiology, Faculty of Medicine, Masaryk University, Brno 62500, Czech Republic; BIOCEV (Biotechnology and Biomedicine Center in Vestec), First Faculty of Medicine, Charles Univer
  • Zenka J; Department of Medical Biology, Faculty of Science, University of South Bohemia, Ceske Budejovice 37005, Czech Republic. Electronic address: jzenka@prf.jcu.cz.
  • Zhuang Z; Neuro-Oncology Branch, National Cancer Institute, NIH, Bethesda 20892, MD, USA. Electronic address: zhengping.zhuang@nih.gov.
  • Pacak K; Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda 20892, MD, USA. Electronic address: karel@mail.nih.gov.
Best Pract Res Clin Endocrinol Metab ; : 101941, 2024 Sep 11.
Article en En | MEDLINE | ID: mdl-39278811
ABSTRACT
Immunotherapy represents a revolutionary advancement in cancer treatment, which has traditionally focused on T cells; however, the role of B cells in cancer immunotherapy has gained interest because of their role in antigen presentation, antibody production, and cytokine release. In this study, we examined the role of B cells in previously developed intratumoral MBTA therapy (mannan-BAM, TLR ligands, and anti-CD40 antibody) in murine models of MTT pheochromocytoma. The results indicated that B cells significantly enhance the success of MBTA therapy, with wild-type mice exhibiting a lower tumor incidence and smaller tumors compared with B cell-deficient mice. Increased IL-6 and TNF-alpha levels indicated severe inflammation and a potential cytokine storm in B cell-deficient mice. Neutralization of TNF-alpha ameliorated these complications but resulted in increased tumor recurrence. The results highlight the important role of B cells in enhancing the immune response and maintaining immune homeostasis during MBTA therapy. Our findings offer new insights into improving therapeutic outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Best Pract Res Clin Endocrinol Metab Asunto de la revista: ENDOCRINOLOGIA / METABOLISMO Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Best Pract Res Clin Endocrinol Metab Asunto de la revista: ENDOCRINOLOGIA / METABOLISMO Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos