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Utilizing innovative implementation strategies for familial hypercholesterolemia: Implementation outcomes from the IMPACT-FH study.
Campbell-Salome, Gemme; Morgan, Kelly M; Gabriel, Jazmine; McGowan, Mary P; Walters, Nicole L; Brangan, Andrew; Tricou, Eric P; Rahm, Alanna K; Sturm, Amy C; Jones, Laney K.
Afiliación
  • Campbell-Salome G; Department of Genomic Health, Research Institute, Geisinger, Danville, PA, 17822, USA (Drs Campbell-Salome, Morgan, Gabriel, Walters, Brangan, Rahm and Jones); Department of Population Health Sciences, Research Institute, Geisinger, Danville, PA, 17822, USA (Dr Campbell-Salome). Electronic address:
  • Morgan KM; Department of Genomic Health, Research Institute, Geisinger, Danville, PA, 17822, USA (Drs Campbell-Salome, Morgan, Gabriel, Walters, Brangan, Rahm and Jones).
  • Gabriel J; Department of Genomic Health, Research Institute, Geisinger, Danville, PA, 17822, USA (Drs Campbell-Salome, Morgan, Gabriel, Walters, Brangan, Rahm and Jones).
  • McGowan MP; Family Heart Foundation, 5548 First Coast Hwy, Suite 204, Fernandina Beach, FL, 32034 (Drs McGowan and Tricou); Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH, 03756, USA (Dr McGowan).
  • Walters NL; Department of Genomic Health, Research Institute, Geisinger, Danville, PA, 17822, USA (Drs Campbell-Salome, Morgan, Gabriel, Walters, Brangan, Rahm and Jones).
  • Brangan A; Department of Genomic Health, Research Institute, Geisinger, Danville, PA, 17822, USA (Drs Campbell-Salome, Morgan, Gabriel, Walters, Brangan, Rahm and Jones).
  • Tricou EP; Family Heart Foundation, 5548 First Coast Hwy, Suite 204, Fernandina Beach, FL, 32034 (Drs McGowan and Tricou).
  • Rahm AK; Department of Genomic Health, Research Institute, Geisinger, Danville, PA, 17822, USA (Drs Campbell-Salome, Morgan, Gabriel, Walters, Brangan, Rahm and Jones).
  • Sturm AC; 23andMe, 223 N Mathilda Ave, Sunnyvale, CA, 94086, USA (Dr Sturm).
  • Jones LK; Department of Genomic Health, Research Institute, Geisinger, Danville, PA, 17822, USA (Drs Campbell-Salome, Morgan, Gabriel, Walters, Brangan, Rahm and Jones); Heart and Vascular Institute, Geisinger, Danville, PA, 17822, USA (Dr Jones).
J Clin Lipidol ; 2024 Jul 31.
Article en En | MEDLINE | ID: mdl-39278768
ABSTRACT

BACKGROUND:

Cascade testing can be highly effective in identifying individuals with familial hypercholesterolemia (FH) and help prevent atherosclerotic cardiovascular disease. The IMPACT-FH cascade testing program offered multiple optimized implementation strategies to improve FH cascade testing uptake.

OBJECTIVE:

Guided by the Conceptual Model of Implementation Research, this study assessed the IMPACT-FH cascade testing program's implementation outcomes.

METHODS:

Implementation outcomes were assessed qualitatively and quantitatively. Interviews were conducted with 33 IMPACT-FH program participants including 15 probands, 12 relatives, and 6 healthcare professionals (HCPs). Transcripts were analyzed using thematic analysis to investigate implementation outcomes. Descriptive statistics were analyzed for scaled implementation outcome measures asked after interviews.

RESULTS:

Participants described adopting strategies offered in the IMPACT-FH program because they presented an opportunity to pursue low-cost FH cascade testing. Participants identified barriers to feasibility including the complexity of disclosing an FH result and offering strategies on, inherent limitations of probands choosing strategies, confusion over testing costs, limitations sharing with relatives' clinicians, discomfort with chatbot technology, and concerns about the workload for HCPs. Participants evaluated the program positively regarding its appropriateness (Mean (M) = 4.70, Standard Deviation (SD) = 0.41), acceptability (M = 4.79, SD = 0.40), and feasibility (M = 4.24, SD = 0.53).

CONCLUSION:

The IMPACT-FH cascade testing program and its strategies were evaluated as valuable to adopt and highly appropriate, acceptable, and feasible by participants. Participants identified areas to enhance the program that could improve FH cascade testing uptake.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Lipidol Asunto de la revista: BIOQUIMICA / METABOLISMO Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Lipidol Asunto de la revista: BIOQUIMICA / METABOLISMO Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos