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An inulin-type polysaccharide from Atractylodis Macrocephalae Rhizoma can relieve psoriasis.
Tang, Xinran; Liu, Lijuan; Wu, Yayun; Zhao, Ya; Lu, Chuanjian; Zhao, Ruizhi.
Afiliación
  • Tang X; State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
  • Liu L; State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
  • Wu Y; State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
  • Zhao Y; State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicin
  • Lu C; State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Neihuan Xilu, Guangzhou Higher Educat
  • Zhao R; State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Neihuan Xilu, Guangzhou Higher Educat
Int J Biol Macromol ; 280(Pt 1): 135667, 2024 Sep 14.
Article en En | MEDLINE | ID: mdl-39278435
ABSTRACT
Atractylodis Macrocephalae Rhizoma (AMR), an herb often found in compounded remedies for psoriasis, is rich in polysaccharides. However, the beneficial effects of AMR polysaccharides on psoriasis remain obscure. In this study, an inulin-type fructan-labelled AMP was extracted from the AMR. AMP has a molecular weight of 5.84 kDa and comprises fructose, glucose, and arabinose at a molar ratio of 9352. Methylation and NMR analyses revealed that AMP comprises a linear backbone of 2,6-linked Fruf or 1,2-linked Fruf with branching 1,2,6-linked Fruf and terminates in T-Glcp. Animal studies verified that AMP can improve imiquimod-induced psoriasis-like skin lesions and downregulate the Il-17a, Il-23, Il-22, Il-6, Il-12, and Tnf-α gene expression. Furthermore, we elucidated the underlying mechanisms using cellular experiments. The ability of AMP to inhibit hyperproliferation and the overexpression of TNF-α, IL-6, and IL-23 genes in human immortal keratinocyte cells (HaCaT) stimulated by lipopolysaccharide was demonstrated. These results indicate that AMP may directly target keratinocytes to suppress excessive proliferation and contribute to anti-inflammatory responses, potentially by blocking the activation of the PI3K/AKT/mTOR pathway. In summary, AMP has demonstrated potential as a prospective treatment strategy for psoriasis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos