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Elevated cerebrospinal fluid neuronal injury biomarkers within 24 hours of onset in infection-triggered acute encephalopathy compared to complex febrile seizures.
Oikawa, Shizuka; Yamaguchi, Hiroshi; Nishiyama, Masahiro; Ito, Tatsuhito; Kawamura, Aoi; Sameshima, Tomohiro; Soma, Kento; Ueda, Takuya; Tokumoto, Shoichi; Ishida, Yusuke; Kurosawa, Hiroshi; Nozu, Kandai; Maruyama, Azusa; Tanaka, Ryojiro; Nagase, Hiroaki.
Afiliación
  • Oikawa S; Department of Pediatrics, Kobe University Graduate School of Medicine, Hyogo, Japan.
  • Yamaguchi H; Department of Pediatrics, Kobe University Graduate School of Medicine, Hyogo, Japan. Electronic address: hiyamagu@med.kobe-u.ac.jp.
  • Nishiyama M; Department of Neurology, Hyogo Prefectural Kobe Children's Hospital, Hyogo, Japan.
  • Ito T; Department of Pediatrics, Kobe University Graduate School of Medicine, Hyogo, Japan.
  • Kawamura A; Department of Pediatrics, Kobe University Graduate School of Medicine, Hyogo, Japan.
  • Sameshima T; Department of Pediatrics, Kobe University Graduate School of Medicine, Hyogo, Japan.
  • Soma K; Department of Neurology, Hyogo Prefectural Kobe Children's Hospital, Hyogo, Japan.
  • Ueda T; Department of Pediatrics, Kobe University Graduate School of Medicine, Hyogo, Japan.
  • Tokumoto S; Department of Pediatrics, Kobe University Graduate School of Medicine, Hyogo, Japan.
  • Ishida Y; Department of Neurology, Hyogo Prefectural Kobe Children's Hospital, Hyogo, Japan.
  • Kurosawa H; Department of Pediatric Critical Care Medicine, Hyogo Prefectural Kobe Children's Hospital, Hyogo, Japan.
  • Nozu K; Department of Pediatrics, Kobe University Graduate School of Medicine, Hyogo, Japan.
  • Maruyama A; Department of Neurology, Hyogo Prefectural Kobe Children's Hospital, Hyogo, Japan.
  • Tanaka R; Department of Emergency and General Pediatrics, Hyogo Prefectural Kobe Children's Hospital, Hyogo, Japan.
  • Nagase H; Department of Pediatrics, Kobe University Graduate School of Medicine, Hyogo, Japan.
J Neurol Sci ; 466: 123238, 2024 Sep 12.
Article en En | MEDLINE | ID: mdl-39278173
ABSTRACT

OBJECTIVE:

This study aimed to measure and compare cerebrospinal fluid neuronal injury biomarkers in the acute phase of complex febrile seizure (CFS) and infection-triggered acute encephalopathy (AE). Furthermore, we determined the pathogenesis of AE with biphasic seizures and late reduced diffusion (AESD).

METHODS:

Pediatric patients with febrile status epilepticus who visited Hyogo Prefectural Kobe Children's Hospital from November 1, 2016, to December 31, 2022, and whose cerebrospinal fluid samples were collected within 24 h of neurological symptom onset were included. Patients were classified as having CFS or infection-triggered AE according to their definitions. Patients with AE were further categorized into AESD or unclassified AE. Cerebrospinal fluid biomarkers (neuron-specific enolase, growth differentiation factor 15 [GDF-15], S100 calcium-binding protein B [S100B], glial fibrillary acidic protein, and tau protein were measured and compared among the groups.

RESULTS:

Total of 63 patients (45 with CFS and 18 with AE) were included. Among the AE patients, nine were classified as having AESD and nine as having unclassified AE. S100B levels were significantly higher in patients with AESD than in patients with CFS (485 pg/ml vs. 175.3 pg/ml) and were even higher in patients with AESD and neurological sequelae (702.4 pg/ml). GDF-15 levels were significantly elevated in patients with AE compared to patients with CFS (85.8 pg/ml vs. 23.6 pg/ml).

CONCLUSIONS:

The elevation of S100B suggests that activated astrocytes may be closely associated with the early pathology of AESD. Elevated GDF-15 levels in infection-triggered AE suggest the activation of defense mechanisms caused by stronger neurological injury.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Neurol Sci Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Neurol Sci Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos