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Nano-alumina induced developmental and neurobehavioral toxicity in the early life stage of zebrafish, associated with mTOR.
Zhang, Ying; He, Kaihong; Wang, Yanhong; Guo, Xinyue; Chen, Jin; Shang, Nan; Chen, Jianping; Zhang, Ping; Zhang, Ling; Niu, Qiao; Zhang, Qinli.
Afiliación
  • Zhang Y; Department of Toxicology, Shanxi Provincial Center for Disease Control and Prevention, Taiyuan, 030012, China.
  • He K; Department of Occupational Medicine, School of public health, Shanxi Medical University, Taiyuan, Shanxi, 030001, China.
  • Wang Y; Department of Occupational Medicine, School of public health, Shanxi Medical University, Taiyuan, Shanxi, 030001, China.
  • Guo X; Department of Occupational Medicine, School of public health, Shanxi Medical University, Taiyuan, Shanxi, 030001, China.
  • Chen J; Department of Occupational Medicine, School of public health, Shanxi Medical University, Taiyuan, Shanxi, 030001, China.
  • Shang N; Department of Occupational Medicine, School of public health, Shanxi Medical University, Taiyuan, Shanxi, 030001, China.
  • Chen J; Department of Occupational Medicine, School of public health, Shanxi Medical University, Taiyuan, Shanxi, 030001, China.
  • Zhang P; Department of Occupational Medicine, School of public health, Shanxi Medical University, Taiyuan, Shanxi, 030001, China.
  • Zhang L; Department of Occupational Medicine, School of public health, Shanxi Medical University, Taiyuan, Shanxi, 030001, China.
  • Niu Q; Department of Occupational Medicine, School of public health, Shanxi Medical University, Taiyuan, Shanxi, 030001, China.
  • Zhang Q; Department of Occupational Medicine, School of public health, Shanxi Medical University, Taiyuan, Shanxi, 030001, China; Department of Pathology, University of Mississippi Medical Center, 2500 N State St., Jackson, MS, 39216, United States. Electronic address: zhangql93061111@126.com.
Aquat Toxicol ; 276: 107086, 2024 Sep 07.
Article en En | MEDLINE | ID: mdl-39277994
ABSTRACT
The study aims to investigate the effects of nano-alumina (AlNPs) on the early development and neurobehavior of zebrafish and the role of mTOR in this process. After embryos and grown-up larvae exposed to AlNPs from 0 to 200 µg/mL, we examined the development, neurobehavior, AlNPs content, and mTOR pathway genes. Moreover, embryos were randomly administered with control, negative control, mTOR knockdown, AlNPs, and mTOR knockdown + AlNPs, then examined for development, neurobehavior, oxidative stress, neurotransmitters, and development genes. As AlNPs increased, swimming speed and distance initially increased and then decreased; thigmotaxis and panic-avoidance reflex substantially decreased in the high-dose AlNPs group; aluminum and nanoparticles considerably accumulated in the 100 µg/mL AlNPs group; AlNPs at high dose decreased mTOR gene and protein levels, stimulating autophagy via increasing ULK1 and ULK2. mTOR knockdown exacerbated the harm to normal development rate, eye and body length, and neurobehavior induced by AlNPs through raising ROS, SOD, and ACH levels but decreasing AchE activity and development genes. Therefore, AlNPs suppress neurobehavior through downregulating mTOR, and mTOR knockdown further aggravates their early development and neurobehavior loss, suggesting mTOR could be a potential target for the toxicity of AlNPs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Aquat Toxicol Asunto de la revista: BIOLOGIA / TOXICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Aquat Toxicol Asunto de la revista: BIOLOGIA / TOXICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos