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Metabolism and epigenetics: drivers of tumor cell plasticity and treatment outcomes.
Gantner, Benjamin N; Palma, Flavio R; Pandkar, Madhura R; Sakiyama, Marcelo J; Arango, Daniel; DeNicola, Gina M; Gomes, Ana P; Bonini, Marcelo G.
Afiliación
  • Gantner BN; Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
  • Palma FR; Department of Medicine, Feinberg School of Medicine and Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.
  • Pandkar MR; Department of Medicine, Feinberg School of Medicine and Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.
  • Sakiyama MJ; Department of Medicine, Feinberg School of Medicine and Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.
  • Arango D; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • DeNicola GM; Department of Metabolism and Physiology, H. Lee Moffitt Cancer Center, Tampa, FL, USA.
  • Gomes AP; Department of Molecular Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA.
  • Bonini MG; Department of Medicine, Feinberg School of Medicine and Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA. Electronic address: marcelo.bonini@northwestern.edu.
Trends Cancer ; 2024 Sep 13.
Article en En | MEDLINE | ID: mdl-39277448
ABSTRACT
Emerging evidence indicates that metabolism not only is a source of energy and biomaterials for cell division but also acts as a driver of cancer cell plasticity and treatment resistance. This is because metabolic changes lead to remodeling of chromatin and reprogramming of gene expression patterns, furthering tumor cell phenotypic transitions. Therefore, the crosstalk between metabolism and epigenetics seems to hold immense potential for the discovery of novel therapeutic targets for various aggressive tumors. Here, we highlight recent discoveries supporting the concept that the cooperation between metabolism and epigenetics enables cancer to overcome mounting treatment-induced pressures. We discuss how specific metabolites contribute to cancer cell resilience and provide perspective on how simultaneously targeting these key forces could produce synergistic therapeutic effects to improve treatment outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Trends Cancer Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Trends Cancer Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos