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Validity of reducing blood culture incubation time for the BD BACTEC FX blood culture system considering microbiological and clinical aspects.
Hashimoto, Takehiro; Yahiro, Takaaki; Khan, Sakirul; Kimitsuki, Kazunori; Nishizono, Akira; Hiramatsu, Kazufumi.
Afiliación
  • Hashimoto T; Hospital Infection Control Center, Oita University Hospital, Oita, Japan. Electronic address: hashimo2013@oita-u.ac.jp.
  • Yahiro T; Department of Microbiology, Oita University Faculty of Medicine, Oita, Japan; Department of Advanced Medical Sciences, Oita University Faculty of Medicine, Oita, Japan.
  • Khan S; Department of Microbiology, Oita University Faculty of Medicine, Oita, Japan; Research Center for Global and Local Infectious Diseases, Oita, Japan.
  • Kimitsuki K; Department of Microbiology, Oita University Faculty of Medicine, Oita, Japan.
  • Nishizono A; Department of Microbiology, Oita University Faculty of Medicine, Oita, Japan; Research Center for Global and Local Infectious Diseases, Oita, Japan.
  • Hiramatsu K; Hospital Infection Control Center, Oita University Hospital, Oita, Japan.
J Infect Chemother ; 2024 Sep 12.
Article en En | MEDLINE | ID: mdl-39276860
ABSTRACT

INTRODUCTION:

A blood culture (BC) test is vital for diagnosing bacteremia in clinical practice. Although incubation time varies among automated BC systems, 4-5 days is deemed to be sufficient time for the BD BACTEC FX blood culture system. This study compared the clinical and microbiological characteristics of true-positive BC samples on day 5 with those within 4 days to reduce missed true bacteremia cases.

METHODS:

We conducted a retrospective study of blood cultures from hospitalized patients between April 2020 and April 2023 at a tertiary care hospital in Japan.

RESULTS:

In total, 12,342 BC sets were collected from 6,567 patients. Gram-positive bacilli other than Bacillus spp. and Corynebacterium spp., non-albicans Candida, and yeasts other than Candida spp. were detected more frequently in BC-positive patients on day 5 than in those within 4 days. The gastrointestinal tract was the portal of entry more frequently on day 5 than within 4 days (25 % vs. 4 %, p = 0.006).

CONCLUSION:

A 4-day incubation period is sufficient for the BD BACTEC FX blood culture system under routine conditions. However, a 5-day incubation period may be warranted when low pathogenicity is suspected or the gastrointestinal tract is suspected as the portal of entry.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Infect Chemother Asunto de la revista: MICROBIOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Infect Chemother Asunto de la revista: MICROBIOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos