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Association of PM2.5 exposure in early pregnancy and maternal liver function: A retrospective cohort study in Shenzhen, China.
Chen, Zhijian; Zhu, Minting; Ni, Weigui; Wu, Bo; Liu, Tao; Lin, Bingyi; Lai, Lijuan; Jing, Yi; Jiang, Long; Ouyang, Zhongai; Hu, Jianxiong; Zheng, Haoqu; Peng, Wan; Yu, Xi; Fan, Jingjie.
Afiliación
  • Chen Z; Department of Preventive Healthcare, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen 518028, China; Faculty of Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, China.
  • Zhu M; School of Public Health, Southern Medical University, Guangzhou 510515, China.
  • Ni W; Department of Preventive Healthcare, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen 518028, China.
  • Wu B; Department of Preventive Healthcare, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen 518028, China.
  • Liu T; China Greater Bay Area Research Center of Environmental Health, School of Medicine, Jinan University, Guangzhou 510632, China; Key Laboratory of Viral Pathogenesis & Infection Prevention and Control, Jinan University, Ministry of Education, Guangzhou 510632, China.
  • Lin B; Department of Preventive Healthcare, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen 518028, China.
  • Lai L; Department of Preventive Healthcare, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen 518028, China.
  • Jing Y; Department of Preventive Healthcare, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen 518028, China.
  • Jiang L; Department of Preventive Healthcare, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen 518028, China.
  • Ouyang Z; Department of Preventive Healthcare, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen 518028, China; School of Public Health, Southern Medical University, Guangzhou 510515, China.
  • Hu J; Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou 510632, China.
  • Zheng H; Faculty of Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, China.
  • Peng W; Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou 510632, China.
  • Yu X; Faculty of Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, China. Electronic address: xyu@must.edu.mo.
  • Fan J; Department of Preventive Healthcare, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen 518028, China. Electronic address: fanfan20221125@163.com.
Environ Res ; 263(Pt 1): 119934, 2024 Sep 12.
Article en En | MEDLINE | ID: mdl-39276834
ABSTRACT

OBJECTIVE:

Studies have shown that fine particulate matter (PM2.5) has adverse effects on the liver function, but epidemiological evidence is limited, especially regarding pregnant women. This study aims to investigate the association between PM2.5 exposure in early pregnancy and maternal liver function during pregnancy.

METHODS:

This retrospective cohort study included 13,342 pregnant participants. PM2.5 and Ozone (O3) exposure level, mean temperature, and relative humidity for each participant were assessed according to their residential address. The levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin (TBIL) were measured during the second and third trimesters. Data on PM2.5 and O3 exposure level were sourced from Tracking Air Pollution in China (TAP), while the mean temperature and relative humidity were obtained from the ERA5 dataset. The Generalized Additive Model (GAM) was used to analyze the associations between PM2.5 exposure and maternal liver function during pregnancy, adjusting for potential confounding factors.

RESULTS:

According to the results, each 10 µg/m3 increase in PM2.5 was associated with an increase of 3.57% (95% CI 0.29%, 6.96%) in ALT and 4.25% (95% CI 2.33%, 6.21%) in TBIL during the second trimester and 4.51% (95% CI 2.59%, 6.47%) in TBIL during the third trimester, respectively. After adjusting for O3, these associations remained significant, and the effect of PM2.5 on ALT during the second trimester was further strengthened. No significant association observed between PM2.5 and AST.

CONCLUSIONS:

PM2.5 exposure in early pregnancy is associated with increasement of maternal ALT and TBIL, suggesting that PM2.5 exposure may have an adverse effect on maternal liver function. Although this finding indicates an association between PM2.5 exposure and maternal liver function, more research is needed to confirm our findings and explore the underlying biological mechanisms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Environ Res Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Environ Res Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos