Your browser doesn't support javascript.
loading
Associations between obstructive sleep apnea and sleep characteristics with chronic kidney disease in rural Pennsylvania.
Sanders, Alison P; Saconi, Bruno; Politis, Maria D; Manus, J Neil; Kirchner, H Lester.
Afiliación
  • Sanders AP; Environmental and Occupational Health, School of Public Health, University of Pittsburgh, USA. Electronic address: APS109@pitt.edu.
  • Saconi B; Population Health Sciences, Geisinger, USA. Electronic address: bsaconi@geisinger.edu.
  • Politis MD; Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, USA. Electronic address: mariadpolitis@gmail.com.
  • Manus JN; Phenomic Analytics & Clinical Data Core, Geisinger, USA. Electronic address: jamanus@geisinger.edu.
  • Kirchner HL; Population Health Sciences, Geisinger, USA. Electronic address: hlkirchner@geisinger.edu.
Sleep Med ; 124: 70-76, 2024 Sep 08.
Article en En | MEDLINE | ID: mdl-39276700
ABSTRACT
STUDY

OBJECTIVES:

To examine the association between moderate-severe obstructive sleep apnea (msOSA) and sleep characteristics with chronic kidney disease (CKD) in a population of rural and urban adults in Pennsylvania.

METHODS:

A cross-sectional study of 23,643 adults who underwent polysomnography (PSG) at a rural healthcare system in Pennsylvania between 2009 and 2019. Serum creatinine was abstracted from electronic health records to calculate estimated glomerular filtration rate (eGFR). CKD was defined as an eGFR <60 mL/min/1.73 m2. msOSA was defined as an apnea-hypoxia index (AHI) ≥15 events/hour. Poisson regression was performed to estimate the prevalence ratio (PR) of CKD for various sleep measures while adjusting for age, sex, race, smoking (never, former, current), body mass index, diabetes, and hypertension at time of PSG.

RESULTS:

In this clinically-referred sample comprised of over one-third (35 %) rural individuals, the prevalence of CKD and msOSA was 9.4 % and 32.1 %, respectively. Patients with CKD had more severe OSA based on AHI and intermittent hypoxia profile and presented worse sleep quality across all studied measures. Having OSA was associated with a 13 % higher prevalence of CKD (95%CI 1.04, 1.22). In addition, for every 5 % increment in sleep efficiency, the prevalence of CKD was 3 % lower (PR = 0.97, 95%CI 0.96, 0.98). Significant associations that were in the expected direction were observed across most sleep characteristics in adjusted models.

CONCLUSIONS:

Moderate-severe OSA, nocturnal hypoxemia, and disruptions to normal sleep duration, continuity, and architecture are associated with increased CKD prevalence in Pennsylvania adults. Management of OSA and/or sleep disturbances may be an opportunity to improve CKD outcomes. The unique health disparities among vulnerable rural populations are deserving of future study.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Sleep Med Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Sleep Med Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos