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Heat stress sensitizes zebrafish embryos to neurological and cardiac toxicity.
Haapanen-Saaristo, Anna-Mari; Virtanen, Noora; Tcarenkova, Elena; Vaparanta, Katri; Ampuja, Minna; Vehniäinen, Eeva-Riikka; Paatero, Ilkka.
Afiliación
  • Haapanen-Saaristo AM; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; Turku Doctoral Programme of Molecular Medicine (TuDMM), University of Turku, Turku, Finland.
  • Virtanen N; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; Faculty of Science and Engineering, Bioscience, Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Åbo Akademi University and University of Turku, Turku, Finland.
  • Tcarenkova E; University of Turku, Department of Cell Biology and Anatomy, Institute of Biomedicine, Finland; Medicity Research Laboratories and Institute of Biomedicine, University of Turku, Finland.
  • Vaparanta K; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; Medicity Research Laboratories and Institute of Biomedicine, University of Turku, Finland.
  • Ampuja M; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Vehniäinen ER; Department of Biology, University of Turku, Finland.
  • Paatero I; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland. Electronic address: ilkka.paatero@utu.fi.
Biochem Biophys Res Commun ; 733: 150682, 2024 Sep 10.
Article en En | MEDLINE | ID: mdl-39276696
ABSTRACT
Global warming increases the risk of dangerous heat waves, which may have deleterious effects on humans and wildlife. Here, we have utilized zebrafish embryos as a model to analyze heat stress and effect of chemical compounds on responses to heat stress. The temperature adaptation limit of zebrafish embryos was 37 °C in behavioural test and 38 °C in cardiac test. Polyaromatic hydrocarbon phenanthrene completely blocked the behavioural adaptation to heat stress. Interestingly, the cardiotoxic effects of lapatinib, phenanthrene and paclitaxel were induced by heat stress. Taken together, our data indicates that motility and cardiac function of zebrafish embryos can be utilized as a model to analyze modulatory effects of compounds on heat stress.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biochem Biophys Res Commun Año: 2024 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biochem Biophys Res Commun Año: 2024 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Estados Unidos