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Functional resilience and overall survival in adults treated for advanced non-small-cell lung cancer.
Presley, Carolyn J; Tang, Joy; Benedict, Jason; Grogan, Madison; Reisinger, Sarah; Janse, Sarah; Wong, Melisa L; Arrato, Nicole A; Davenport, Ashley; Shields, Peter G; Andersen, Barbara L.
Afiliación
  • Presley CJ; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA. Electronic address: carolyn.presley@osumc.edu.
  • Tang J; Divisions of Hematology and Medical Oncology Fellowship Program, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
  • Benedict J; Center for Biostatistics, Department of Biomedical Informatics, The Ohio State University, Columbus, OH, USA.
  • Grogan M; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
  • Reisinger S; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
  • Janse S; Center for Biostatistics, Department of Biomedical Informatics, The Ohio State University, Columbus, OH, USA.
  • Wong ML; Division of Research, Kaiser Permanente Northern California, The Permanente Medical Group, Oakland, CA, USA; Division of Geriatrics, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
  • Arrato NA; Department of Psychology, The Ohio State University, Columbus, OH, USA.
  • Davenport A; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
  • Shields PG; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
  • Andersen BL; Department of Psychology, The Ohio State University, Columbus, OH, USA.
Lung Cancer ; 196: 107953, 2024 Sep 07.
Article en En | MEDLINE | ID: mdl-39276617
ABSTRACT

PURPOSE:

As more treatments emerge for advanced, stage IV non-small-cell lung cancer (NSCLC), oncologists have difficulty predicting functional resiliency versus functional decline throughout cancer treatment. Our study evaluates functional resilience among patients with advanced NSCLC.

METHODS:

Functional status was evaluated through 12 months of follow-up based on disability score using the modified EQ-5D-5L (mEQ-5D-5L) survey. Participants were classified into 4 groups functional maintenance, decline, resilient, or variable. Characteristics of 207 participants with newly diagnosed NSCLC included demographics, comorbidities, baseline Eastern Cooperative Oncology Group (ECOG) performance status (PS), mEQ-5D-5L scores, psychological symptoms, and lung cancer-specific symptoms. Treatment toxicity and grade were recorded. Resilience was defined as improvement from baseline disability scores. A 1-point increase in functional status score represents a 0.5 standard deviation change on the mEQ-5D-5L. Differences between the 4 groups were determined through Fisher's exact test or ANOVA. Kaplan-Meier curves describe overall survival (baseline through 18 months) stratified by baseline mEQ-5D-5L scores.

RESULTS:

Among participants, 42.0 % maintained functional status, 37.7 % experienced functional decline, 10.6 % were resilient, and 9.7 % had variable functional status. Participants with the best baseline function (score of 0) had the longest overall survival and participants with the worst baseline function (score of 5 + ) had the shortest overall survival. Among the healthiest patients, early score increases indicated shorter overall survival. Baseline ECOG PS was not associated with overall survival (p = 0.47).

CONCLUSION:

Baseline functional status may help better predict functional resiliency and overall survival than ECOG PS among patients receiving treatment for advanced NSCLC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Lung Cancer Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Lung Cancer Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article Pais de publicación: Irlanda