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Phosphate-binding proteins and peptides: from molecular mechanisms to potential applications.
Mayer, Brooke K; Hutchison, Justin M; McLamore, Eric S; Torres, Maria; Venkiteshwaran, Kaushik.
Afiliación
  • Mayer BK; Department of Civil, Construction and Environmental Engineering, Marquette University, Milwaukee, WI, USA. Electronic address: Brooke.Mayer@marquette.edu.
  • Hutchison JM; Department of Civil, Environmental & Architectural Engineering, University of Kansas, Lawrence, KS, USA.
  • McLamore ES; Environmental Engineering and Earth Sciences, Clemson University, Clemson, SC, USA; Agricultural Sciences, Clemson University, Clemson, SC, USA.
  • Torres M; Department of Plant and Environmental Sciences, Clemson University, Clemson, SC, USA.
  • Venkiteshwaran K; Department of Civil, Coastal and Environmental Engineering, University of South Alabama, Mobile, AL, USA.
Curr Opin Biotechnol ; 90: 103199, 2024 Sep 12.
Article en En | MEDLINE | ID: mdl-39276616
ABSTRACT
Selective binding of phosphate is vital to multiple aims including phosphate transport into cells and phosphate-targeted applications such as adsorption-based water treatment and sensing. High-affinity phosphate-binding proteins and peptides offer a nature-inspired means of efficiently binding and separating phosphate from complex matrices. The binding protein PstS is characterized by a Venus flytrap topology that confers exceptional phosphate affinity and selectivity, and is effective even at low phosphate concentrations, all of which are essential for applications such as phosphate sensing, removal, and recovery. The binding event is reversible under controlled conditions, making it germane to catch-and-release objectives that advance phosphorus sustainability. Peptides such as the P loop motif are also promising for such applications. Future advances in protein/peptide design can contribute to increased implementation in engineered systems.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Opin Biotechnol Asunto de la revista: BIOTECNOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Opin Biotechnol Asunto de la revista: BIOTECNOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido