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Letrozole-induced reversible acute heart failure.
Sekmek, Serhat; Bayram, Dogan; Seven, Ismet; Perkin, Perihan; Bal, Oznur; Algin, Efnan.
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  • Sekmek S; Department of Medical Oncology, Ankara Bilkent City Hospital, Ankara, Turkey.
  • Bayram D; Department of Medical Oncology, Ankara Bilkent City Hospital, Ankara, Turkey.
  • Seven I; Department of Medical Oncology, Ankara Bilkent City Hospital, Ankara, Turkey.
  • Perkin P; Department of Medical Oncology, Ankara Bilkent City Hospital, Ankara, Turkey.
  • Bal O; Department of Medical Oncology, Ankara Bilkent City Hospital, Ankara, Turkey.
  • Algin E; Department of Medical Oncology, Ankara Bilkent City Hospital, Ankara, Turkey.
J Oncol Pharm Pract ; : 10781552241284908, 2024 Sep 13.
Article en En | MEDLINE | ID: mdl-39275843
ABSTRACT

INTRODUCTION:

Letrozole is an aromatase inhibitor (AI), which suppresses plasma estrogen levels by inhibiting the aromatase enzyme, that causes the conversion of androgens to estrogen in peripheral tissues. There is very few information in the literature regarding the development of acute heart failure after AI use. We would like to report a case of a patient who was started letrozole for hormonal treatment and developed acute heart failure due to this. CASE REPORT Fifty-seven-year-old woman with hormone positive breast cancer was operated after neoadjuvant chemotherapy and received radiotherapy. Letrozole treatment was initiated after radiotherapy and the patient presented to the emergency department after two weeks with cough and dyspnea. Ejection fraction decreased to 20% and acute heart failure developed. MANAGEMENT AND

OUTCOME:

Letrozole treatment was stopped. Afterwards, improvement in the patient's cardiac functions was observed. Letrozole-induced heart failure was thought to be reversible.

DISCUSSION:

Letrozole is one of the most commonly used HT in the treatment of hormone positive breast cancer. It may rarely cause cardiac side effects. It is very important to make patients aware of these issues and to be consulted by cardiology in case of possible cardiac symptoms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Oncol Pharm Pract Asunto de la revista: FARMACIA Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Oncol Pharm Pract Asunto de la revista: FARMACIA Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido