Your browser doesn't support javascript.
loading
Wirelessly Powered Visible Light-Emitting Implant for Surgical Guidance during Lumpectomy.
Rho, Sunghoon; Stillwell, Roy A; Yan, Kedi; de Almeida Barreto, Ana Flavia Borges; Smith, Joshua R; Fay, Patrick; Police, Alice M; O'Sullivan, Thomas D.
Afiliación
  • Rho S; Department of Electrical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
  • Stillwell RA; Department of Electrical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
  • Yan K; Department of Electrical and Computer Engineering, University of Washington, Seattle, WA 98195, USA.
  • de Almeida Barreto AFB; Department of Electrical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
  • Smith JR; Department of Electrical and Computer Engineering, University of Washington, Seattle, WA 98195, USA.
  • Fay P; Allen School of Computer Science and Engineering, University of Washington, Seattle, WA 98195, USA.
  • Police AM; Department of Electrical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
  • O'Sullivan TD; Monument Health Cancer Care Institute, 353 Fairmont Boulevard Rapid City, Rapid City, SD 57701, USA.
Sensors (Basel) ; 24(17)2024 Aug 30.
Article en En | MEDLINE | ID: mdl-39275550
ABSTRACT
Achieving negative surgical margins, defined as no tumor found on the edges of the resected tissue, during lumpectomy for breast cancer is critical for mitigating the risk of local recurrence. To identify nonpalpable tumors that cannot be felt, pre-operative placements of wire and wire-free localization devices are typically employed. Wire-free localization approaches have significant practical advantages over wired techniques. In this study, we introduce an innovative localization system comprising a light-emitting diode (LED)-based implantable device and handheld system. The device, which is needle injectable and wire free, utilizes multiple wirelessly powered LEDs to provide direct visual guidance for lumpectomy. Two distinct colors, red and blue, provide a clear indication of tissue depth blue light is absorbed strongly in tissue, visible within a close range of <1 cm, while red light remains visible through several centimeters of tissue. The LEDs, integrated with an impedance-matching circuit and receiver coil, are encapsulated in biocompatible epoxy for injection with a 12 G needle. Our findings demonstrate that the implant exhibits clearly perceivable depth-dependent color changes and remains visible through >2 cm of ex vivo chicken breast and bovine muscle tissue using less than 4 W of transmitted power from a handheld antenna. These miniaturized needle-injectable localization devices show promise for improving surgical guidance of nonpalpable breast tumors.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Mastectomía Segmentaria / Tecnología Inalámbrica / Luz Límite: Animals / Female / Humans Idioma: En Revista: Sensors (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Mastectomía Segmentaria / Tecnología Inalámbrica / Luz Límite: Animals / Female / Humans Idioma: En Revista: Sensors (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza