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Human Milk Oligosaccharides and Their Pivotal Role in Gut-Brain Axis Modulation and Neurologic Development: A Narrative Review to Decipher the Multifaceted Interplay.
Falsaperla, Raffaele; Sortino, Vincenzo; Gambilonghi, Francesco; Vitaliti, Giovanna; Striano, Pasquale.
Afiliación
  • Falsaperla R; Neonatal Intensive Care Unit and Neonatal Accompaniment Unit, Azienda Ospedaliero-Universitaria Policlinico "Rodolico-San Marco", San Marco Hospital, University of Catania, 95123 Catania, Italy.
  • Sortino V; Unit of Pediatrics and Pediatric Emergency, Azienda Ospedaliero-Universitaria Policlinico "Rodolico-San Marco", San Marco Hospital, University of Catania, 95123 Catania, Italy.
  • Gambilonghi F; Department of Medical Science-Pediatrics, University of Ferrara, 44124 Ferrara, Italy.
  • Vitaliti G; Unit of Pediatrics and Pediatric Emergency, Azienda Ospedaliero-Universitaria Policlinico "Rodolico-San Marco", San Marco Hospital, University of Catania, 95123 Catania, Italy.
  • Striano P; Postgraduate Training Program in Pediatrics, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
Nutrients ; 16(17)2024 Sep 05.
Article en En | MEDLINE | ID: mdl-39275324
ABSTRACT

BACKGROUND:

Human milk oligosaccharides (HMOs), which are unique bioactive components in human milk, are increasingly recognized for their multifaceted roles in infant health. A deeper understanding of the nexus between HMOs and the gut-brain axis can revolutionize neonatal nutrition and neurodevelopmental strategies.

METHODS:

We performed a narrative review using PubMed, Embase, and Google Scholar to source relevant articles. The focus was on studies detailing the influence of HMOs on the gut and brain systems, especially in neonates. Articles were subsequently synthesized based on their exploration into the effects and mechanisms of HMOs on these interconnected systems.

RESULTS:

HMOs significantly influence the neonatal gut-brain axis. Specific concentrations of HMO, measured 1 and 6 months after birth, would seem to agree with this hypothesis. HMOs are shown to influence gut microbiota composition and enhance neurotransmitter production, which are crucial for brain development. For instance, 2'-fucosyllactose has been demonstrated to support cognitive development by fostering beneficial gut bacteria that produce essential short-chain fatty acids.

CONCLUSIONS:

HMOs serve as crucial modulators of the neonatal gut-brain axis, underscoring their importance in infant nutrition and neurodevelopment. Their dual role in shaping the infant gut while influencing brain function presents them as potential game-changers in neonatal health strategies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligosacáridos / Microbioma Gastrointestinal / Eje Cerebro-Intestino / Fenómenos Fisiológicos Nutricionales del Lactante / Leche Humana Límite: Female / Humans / Infant / Newborn Idioma: En Revista: Nutrients Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligosacáridos / Microbioma Gastrointestinal / Eje Cerebro-Intestino / Fenómenos Fisiológicos Nutricionales del Lactante / Leche Humana Límite: Female / Humans / Infant / Newborn Idioma: En Revista: Nutrients Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza