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Can Faecal Zonulin and Calprotectin Levels Be Used in the Diagnosis and Follow-Up in Infants with Milk Protein-Induced Allergic Proctocolitis?
Czaja-Bulsa, Grazyna; Bulsa, Karolina; Lokiec, Monika; Drozd, Arleta.
Afiliación
  • Czaja-Bulsa G; Chair and Department of Paediatrics and Paediatric Nursing, Pomeranian Medical University, 70-204 Szczecin, Poland.
  • Bulsa K; Szczecin Outpatient Clinic, 71-050 Szczecin, Poland.
  • Lokiec M; Clinical Department of Paediatrics University Hospital, 65-046 Zielona Góra, Poland.
  • Drozd A; Department of Human Nutrition and Metabolomics, Pomeranian Medical University, 70-204 Szczecin, Poland.
Nutrients ; 16(17)2024 Sep 02.
Article en En | MEDLINE | ID: mdl-39275265
ABSTRACT

OBJECTIVE:

The aim of our study was to investigate whether a 1-month-long milk-free diet results in a reduction in faecal calprotectin (FC) and faecal-zonulin-related proteins (FZRP) in children with milk-protein-induced allergic proctocolitis (MPIAP). MATERIALS AND

METHODS:

This is a single-centre, prospective, observational cohort study involving 86 infants with MPIAP, aged 1-3 months, and 30 healthy controls of the same age. The FC and FZRP were marked using the ELISA method (IDK® Calprotectin or Zonulin ELISA Kit, Immunodiagnostik AG, Bensheim, Germany). The diagnosis of MPIAP was confirmed with an open milk challenge test.

RESULTS:

FFC and FZRP proved useful in evaluating MPIAP treatment with a milk-free diet, and the resolution of allergic symptoms and a significant (p = 0.0000) decrease in the concentrations of both biomarkers were observed after 4 weeks on the diet. The FC and FZRP concentrations were still higher than in the control group. A high variability of FC concentrations was found in all the study groups. An important limitation is the phenomenon of FZRP not being produced in all individuals, affecting one in five infants.

CONCLUSIONS:

FC and FZRP can be used to monitor the resolution of colitis in infants with MPIAP treated with a milk-free diet, indicating a slower resolution of allergic inflammation than of allergic symptoms. The diagnosis of MPIAP on the basis of FC concentrations is subject to considerable error, due to the high individual variability of this indicator. FZRP is a better parameter, but this needs further research, as these are the first determinations in infants with MPIAP.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proctocolitis / Precursores de Proteínas / Haptoglobinas / Biomarcadores / Hipersensibilidad a la Leche / Complejo de Antígeno L1 de Leucocito / Heces / Proteínas de la Leche Límite: Female / Humans / Infant / Male Idioma: En Revista: Nutrients Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proctocolitis / Precursores de Proteínas / Haptoglobinas / Biomarcadores / Hipersensibilidad a la Leche / Complejo de Antígeno L1 de Leucocito / Heces / Proteínas de la Leche Límite: Female / Humans / Infant / Male Idioma: En Revista: Nutrients Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza