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Molecular Mechanisms of Healthy Aging: The Role of Caloric Restriction, Intermittent Fasting, Mediterranean Diet, and Ketogenic Diet-A Scoping Review.
Surugiu, Roxana; Iancu, Mihaela Adela; Vintilescu, Ștefanița Bianca; Stepan, Mioara Desdemona; Burdusel, Daiana; Genunche-Dumitrescu, Amelia Valentina; Dogaru, Carmen-Adriana; Dumitra, Gheorghe Gindrovel.
Afiliación
  • Surugiu R; Department of Biochemistry, University of Medicine and Pharmacy of Craiova, St. Petru Rares, No. 2-4, 200433 Craiova, Romania.
  • Iancu MA; Department of Internal Medicine (Cardiology, Gastroenterology, Hepatology, Rheumatology, Geriatrics), Family Medicine, Labor Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
  • Vintilescu ȘB; Department of Infant Care-Pediatrics-Neonatology, University of Medicine and Pharmacy of Craiova, St. Petru Rares, No. 2-4, 200433 Craiova, Romania.
  • Stepan MD; Department of Infant Care-Pediatrics-Neonatology, University of Medicine and Pharmacy of Craiova, St. Petru Rares, No. 2-4, 200433 Craiova, Romania.
  • Burdusel D; Department of Biochemistry, University of Medicine and Pharmacy of Craiova, St. Petru Rares, No. 2-4, 200433 Craiova, Romania.
  • Genunche-Dumitrescu AV; Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, St. Petru Rares, No. 2-4, 200433 Craiova, Romania.
  • Dogaru CA; Department of Family Medicine, University of Medicine and Pharmacy of Craiova, St. Petru Rareș, No. 2-4, 200349 Craiova, Romania.
  • Dumitra GG; Department of Family Medicine, University of Medicine and Pharmacy of Craiova, St. Petru Rareș, No. 2-4, 200349 Craiova, Romania.
Nutrients ; 16(17)2024 Aug 28.
Article en En | MEDLINE | ID: mdl-39275194
ABSTRACT
As the population ages, promoting healthy aging through targeted interventions becomes increasingly crucial. Growing evidence suggests that dietary interventions can significantly impact this process by modulating fundamental molecular pathways. This review focuses on the potential of targeted dietary strategies in promoting healthy aging and the mechanisms by which specific nutrients and dietary patterns influence key pathways involved in cellular repair, inflammation, and metabolic regulation. Caloric restriction, intermittent fasting, the Mediterranean diet, as well as the ketogenic diet showed promising effects on promoting healthy aging, possibly by modulating mTORC1 AMPK, an insulin signaling pathway. By understanding the intricate interplay between diet and molecular pathways, we can develop personalized dietary strategies that not only prevent age-related diseases, but also promote overall health and well-being throughout the aging process.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ayuno / Restricción Calórica / Dieta Mediterránea / Dieta Cetogénica / Envejecimiento Saludable Límite: Humans Idioma: En Revista: Nutrients Año: 2024 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ayuno / Restricción Calórica / Dieta Mediterránea / Dieta Cetogénica / Envejecimiento Saludable Límite: Humans Idioma: En Revista: Nutrients Año: 2024 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Suiza