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TSPO Radioligands for Neuroinflammation: An Overview.
Salerno, Silvia; Viviano, Monica; Baglini, Emma; Poggetti, Valeria; Giorgini, Doralice; Castagnoli, Jacopo; Barresi, Elisabetta; Castellano, Sabrina; Da Settimo, Federico; Taliani, Sabrina.
Afiliación
  • Salerno S; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
  • Viviano M; Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy.
  • Baglini E; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
  • Poggetti V; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
  • Giorgini D; Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy.
  • Castagnoli J; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
  • Barresi E; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
  • Castellano S; Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy.
  • Da Settimo F; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
  • Taliani S; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
Molecules ; 29(17)2024 Sep 05.
Article en En | MEDLINE | ID: mdl-39275061
ABSTRACT
The translocator protein (TSPO) is predominately localized on the outer mitochondrial membrane in steroidogenic cells. In the brain, TSPO expression, low under normal conditions, results upregulated in response to glial cell activation, that occurs in neuroinflammation. As a consequence, TSPO has been extensively studied as a biomarker of such conditions by means of TSPO-targeted radiotracers. Although [11C]-PK11195, the prototypical TSPO radioligand, is still widely used for in vivo studies, it is endowed with severe limitations, mainly low sensitivity and poor amenability to quantification. Consequently, several efforts have been focused on the design of new radiotracers for the in vivo imaging of TSPO. The present review will provide an outlook on the latest advances in TSPO radioligands for neuroinflammation imaging. The final goal is to pave the way for (radio)chemists in the future design and development of novel effective and sensitive radiopharmaceuticals targeting TSPO.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de GABA / Radiofármacos / Enfermedades Neuroinflamatorias Límite: Animals / Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de GABA / Radiofármacos / Enfermedades Neuroinflamatorias Límite: Animals / Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza