Multi-Sensitive Au NCs/5-FU@Carr-LA Composite Hydrogels for Targeted Multimodal Anti-Tumor Therapy.

Qi, Chunxia; Li, Ang; Wu, Baoming; Wang, Peisan

Qi, Chunxia; Li, Ang; Wu, Baoming; Wang, Peisan.

Afiliación

Qi C; Department of Chemical and Pharmaceutical Engineering, Hefei Normal University, Hefei 230601, China.
Li A; School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei 230032, China.
Wu B; Inflammation and Immune Mediated Diseases Laboratory of Anhu Province, Hefei 230032, China.
Wang P; School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei 230032, China.

Molecules ; 29(17)2024 Aug 27.

Article en En | MEDLINE | ID: mdl-39274898

ABSTRACT

ABSTRACT

Multifunctional targeted drug delivery systems have been explored as a novel cancer treatment strategy to overcome limitations of traditional chemotherapy. The combination of photodynamic therapy and chemotherapy has been shown to enhance efficacy, but the phototoxicity of traditional photosensitizers is a challenge. In this study, we prepared a multi-sensitive composite hydrogel containing gold nanoclusters (Au NCs) and the temperature-sensitive antitumor drug 5-fluorourac il (5-FU) using carboxymethyl cellulose (Carr) as a dual-functional template. Au NCs were synthesized using sodium borohydride as a reducing agent and potassium as a promoter. The resulting Au NCs were embedded in the Carr hydrogel, which was then conjugated with lactobionic acid (LA) as a targeting ligand. The resulting Au NCs/5-FU@Carr-LA composite hydrogel was used for synergistic photodynamic therapy (PDT), photothermal therapy (PTT), and chemotherapy. Au NCs/5-FU@Carr-LA releases the drug faster at pH 5.0 due to the acid sensitivity of the Carr polymer chain. In addition, at 50 °C, the release rate of Au NCs/5-FU@Carr-LA is 78.2%, indicating that the higher temperature generated by the photothermal effect is conducive to the degradation of Carr polymer chains. The Carr hydrogel stabilized the Au NCs and acted as a matrix for drug loading, and the LA ligand facilitated targeted delivery to tumor cells. The composite hydrogel exhibited excellent biocompatibility and synergistic antitumor efficacy, as demonstrated by in vitro and in vivo experiments. In addition, the hydrogel had thermal imaging capabilities, making it a promising multifunctional platform for targeted cancer therapy.

Asunto(s)

Fluorouracilo; Oro; Hidrogeles; Nanopartículas del Metal; Fotoquimioterapia; Oro/química; Hidrogeles/química; Fluorouracilo/farmacología; Fluorouracilo/química; Animales; Nanopartículas del Metal/química; Ratones; Humanos; Fotoquimioterapia/métodos; Antineoplásicos/farmacología; Antineoplásicos/química; Sistemas de Liberación de Medicamentos; Línea Celular Tumoral; Carboximetilcelulosa de Sodio/química; Fármacos Fotosensibilizantes/química; Fármacos Fotosensibilizantes/farmacología; Liberación de Fármacos; Terapia Fototérmica/métodos

Palabras clave

Carr; chemotherapy; composite hydrogel; gold nanoclusters; multi-modal antitumor therapy; photodynamic therapy; photothermal therapy

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Hidrogeles / Nanopartículas del Metal / Fluorouracilo / Oro Límite: Animals / Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza

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