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The Impact of Tumor Elongation on Facial Nerve Outcome after Surgery for Koos Grade 3 and 4 Vestibular Schwannomas in the Semi-Sitting Position via the Retrosigmoid Approach.
Glieme, Franziska; Haddad, Lisa; Arlt, Felix; Vychopen, Martin; Seidel, Clemens; Barrantes-Freer, Alonso; Güresir, Erdem; Wach, Johannes.
Afiliación
  • Glieme F; Department of Neurosurgery, University Hospital Leipzig, University of Leipzig, 04103 Leipzig, Germany.
  • Haddad L; Comprehensive Cancer Center Central Germany, Partner Site Leipzig, 04103 Leipzig, Germany.
  • Arlt F; Department of Neurosurgery, University Hospital Leipzig, University of Leipzig, 04103 Leipzig, Germany.
  • Vychopen M; Comprehensive Cancer Center Central Germany, Partner Site Leipzig, 04103 Leipzig, Germany.
  • Seidel C; Department of Neurosurgery, University Hospital Leipzig, University of Leipzig, 04103 Leipzig, Germany.
  • Barrantes-Freer A; Comprehensive Cancer Center Central Germany, Partner Site Leipzig, 04103 Leipzig, Germany.
  • Güresir E; Department of Neurosurgery, University Hospital Leipzig, University of Leipzig, 04103 Leipzig, Germany.
  • Wach J; Comprehensive Cancer Center Central Germany, Partner Site Leipzig, 04103 Leipzig, Germany.
J Clin Med ; 13(17)2024 Sep 08.
Article en En | MEDLINE | ID: mdl-39274531
ABSTRACT

Background:

Facial nerve paralysis is a severe dysfunction after vestibular schwannoma (VS) surgery.

Methods:

This monocentric study analyzed 61 patients who underwent sporadic VS surgery in a standardized manner. The primary endpoint was the facial nerve outcome (FNO) at 3 months after VS surgery. FNO was dichotomized into "good" (House-Brackmann (HB) score ≤ 2) and "poor" (HB > 2).

Results:

Poor FNO was observed in 11 patients (18.0%) at 3 months after VS surgery. Radiomic tumor shape features were analyzed, and the AUC of elongation in the prediction of a poor HB at 3 months was 0.70 (95% CI 0.56-0.85, p = 0.03) and the optimum threshold value (≤/>0.35) yielded a sensitivity and specificity of 64.0% and 75.4%, respectively. Multivariable logistic regression analyses considering the extent of resection (tumor volume (sex (female/male), and elongation (≤/>0.35) revealed that more elongated VSs (≤0.35; OR 5.8; 95%CI 1.2-28.2; p = 0.03) and those with an increased EoR (≥93.4%; OR 6.5; 95%CI 1.0-42.5; p = 0.05) are independently associated with poorer FNO at 3 months after surgery.

Conclusions:

Highly elongated VS shape seems to be a risk factor for worsened facial nerve outcome at 3 months after surgery for Koos grade 3 and 4 tumors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza