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Clinical Risk Factors and First Gestational 75 g OGTT May Predict Recurrent and New-Onset Gestational Diabetes in Multiparous Women.
Mirabelli, Maria; Tocci, Vera; Chiefari, Eusebio; Iuliano, Stefano; Brunetti, Francesco S; Misiti, Roberta; Giuliano, Stefania; Greco, Marta; Foti, Daniela P; Brunetti, Antonio.
Afiliación
  • Mirabelli M; Department of Health Sciences, University "Magna Græcia" of Catanzaro, 88100 Catanzaro, Italy.
  • Tocci V; Operative Unit of Endocrinology, "Renato Dulbecco" University Hospital, 88100 Catanzaro, Italy.
  • Chiefari E; Department of Health Sciences, University "Magna Græcia" of Catanzaro, 88100 Catanzaro, Italy.
  • Iuliano S; Operative Unit of Endocrinology, "Renato Dulbecco" University Hospital, 88100 Catanzaro, Italy.
  • Brunetti FS; Department of Health Sciences, University "Magna Græcia" of Catanzaro, 88100 Catanzaro, Italy.
  • Misiti R; Operative Unit of Endocrinology, "Renato Dulbecco" University Hospital, 88100 Catanzaro, Italy.
  • Giuliano S; Department of Health Sciences, University "Magna Græcia" of Catanzaro, 88100 Catanzaro, Italy.
  • Greco M; Department of Health Sciences, University "Magna Græcia" of Catanzaro, 88100 Catanzaro, Italy.
  • Foti DP; Operative Unit of Clinical Pathology, "Renato Dulbecco" Hospital, 88100 Catanzaro, Italy.
  • Brunetti A; Department of Experimental and Clinical Medicine, University "Magna Græcia" of Catanzaro, 88100 Catanzaro, Italy.
J Clin Med ; 13(17)2024 Sep 02.
Article en En | MEDLINE | ID: mdl-39274417
ABSTRACT

Background:

Women who experience gestational diabetes mellitus (GDM) during their first pregnancy are at a high risk of developing GDM again in subsequent pregnancies. Even mothers with no previous history of GDM may develop the condition in a new pregnancy.

Methods:

In this retrospective cross-sectional observational study, 759 multiparous women tested for GDM in two successive pregnancies using the 75 g OGTT (IADPSG criteria) were enrolled. The OGTT was performed at 24-28 weeks' gestation or earlier if there was a history of GDM. Participants were categorized into four groups women with normal glucose tolerance (NGT) in both pregnancies (n = 493), women with a first occurrence of GDM in their second pregnancy (n = 74), women with non-recurrent GDM in their second pregnancy (n = 92), and women with recurrent GDM in their second pregnancy (n = 100).

Results:

Intergroup comparisons revealed clinical predictors of GDM in the first pregnancy (family history of type 2 diabetes, PCOS, advanced maternal age, pregravid obesity) and in the second pregnancy (interpregnancy BMI gain), as well as predictors of recurrent GDM (pregravid obesity, PCOS). A positive correlation was observed between the OGTT glucose levels of consecutive pregnancies. Adjusted logistic regression indicated that a higher 1-h post-load glucose level (≥130 mg/dL) during the first pregnancy significantly increased the likelihood of new-onset GDM in the second pregnancy (OR 2.496), whereas a higher 2-h post-load glucose level (≥153 mg/dL) at the first diagnostic OGTT increased the likelihood of recurrent GDM (OR 2.214).

Conclusions:

Clinical risk factors and post-load glucose levels during the first gestational 75 g OGTT can help predict new-onset or recurrent GDM in multiparous women.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza