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Grover's Disease Association with Cutaneous Keratinocyte Cancers: More than a Coincidence?
Nedelcu, Roxana; Dobre, Alexandra; Turcu, Gabriela; Andrei, Razvan; Balasescu, Elena; Pantelimon, Florentina; David-Niculescu, Mihaela; Dobritoiu, Adina; Radu, Raluca; Zaharia, Georgiana Roxana; Hulea, Ionela; Brinzea, Alice; Manea, Lorena; Gherghiceanu, Mihaela; Ion, Daniela.
Afiliación
  • Nedelcu R; Pathophysiology Department, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
  • Dobre A; Derma360 Clinic, 011273 Bucharest, Romania.
  • Turcu G; Pathophysiology Department, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
  • Andrei R; Oncologic Dermatology Department, Elias Emergency University Hospital, 011461 Bucharest, Romania.
  • Balasescu E; Pathophysiology Department, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
  • Pantelimon F; Derma360 Clinic, 011273 Bucharest, Romania.
  • David-Niculescu M; Dermatology Department, Colentina Clinical Hospital, 020125 Bucharest, Romania.
  • Dobritoiu A; Dermatology Department, Colentina Clinical Hospital, 020125 Bucharest, Romania.
  • Radu R; Synevo, 014192 Bucharest, Romania.
  • Zaharia GR; Pathophysiology Department, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
  • Hulea I; Derma360 Clinic, 011273 Bucharest, Romania.
  • Brinzea A; Derma360 Clinic, 011273 Bucharest, Romania.
  • Manea L; Dermatology Department, "Grigore Alexandrescu" Emergency Pediatric Hospital, 011743 Bucharest, Romania.
  • Gherghiceanu M; Derma360 Clinic, 011273 Bucharest, Romania.
  • Ion D; Dermatology Department, Central Military Emergency Hospital "Dr.Carol Davila", 010242 Bucharest, Romania.
Int J Mol Sci ; 25(17)2024 Sep 08.
Article en En | MEDLINE | ID: mdl-39273660
ABSTRACT
Better mechanistic understanding of desmosome disruption and acantholysis in Grover's disease (GD) may improve management of this disease. Recent molecular studies highlighted promising pathways to be explored by directly comparing GD and selected features of associated skin diseases. The association between GD and cutaneous keratinocyte carcinomas, the most prevalent non-melanoma skin cancers (NMSC), is not completely characterized. To review the medical literature regarding GD-associated cutaneous keratinocyte cancers, focusing on molecular features, pathophysiological mechanisms, and disease associations, to help guide future research and patient management. GD has been associated with a variety of skin conditions, but its association with skin cancers has been rarely reported. Between 1983 and 2024, only nine scientific papers presented data supporting this association. Interestingly, we found that GD may mimic multiple NMSCs, as few authors reported GD cases misdiagnosed as multiple cutaneous squamous cell carcinomas for more than 4 years or the presence of superficial basal cell carcinoma-like areas associated with focal acantholysis. In

conclusion:

(a) GD may be an imitator of multiple NMSCs, and (b) the relationship between GD and NMSCs may reveal promising pathways for the mechanistic understanding of desmosome disruption and acantholysis in GD and may even lead to its reclassification as a distinctive syndrome.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Queratinocitos / Acantólisis Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Queratinocitos / Acantólisis Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Suiza